ID   A0A182WXG4_ANOQN        Unreviewed;       869 AA.
AC   A0A182WXG4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Sulfatase N-terminal domain-containing protein {ECO:0000259|Pfam:PF00884};
OS   Anopheles quadriannulatus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA002224-PA, ECO:0000313|Proteomes:UP000076407};
RN   [1] {ECO:0000313|Proteomes:UP000076407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AQUA002224-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA002224-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182WXG4; -.
DR   STRING; 34691.A0A182WXG4; -.
DR   EnsemblMetazoa; AQUA002224-RA; AQUA002224-PA; AQUA002224.
DR   VEuPathDB; VectorBase:AQUA002224; -.
DR   Proteomes; UP000076407; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:UniProt.
DR   CDD; cd16029; 4-S; 1.
DR   CDD; cd22209; EMC10; 1.
DR   Gene3D; 3.30.1120.10; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR047115; ARSB.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR   PANTHER; PTHR10342:SF264; MIP05773P-RELATED; 1.
DR   Pfam; PF21203; ECM10; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..869
FT                   /note="Sulfatase N-terminal domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008142108"
FT   TRANSMEM        577..598
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        845..862
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          34..359
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
SQ   SEQUENCE   869 AA;  97006 MW;  1CD69F9D08CFFC14 CRC64;
     MTHLTTPLLV CIIVTVGYRA LAVAAYGQQP PKRPHIVLIT ADDMGWNDVG FHGSNQIATP
     HIDALAYDGV ILNRHYSAPM CTPSRAALMT GRHPINVGMQ HYVIDSDEPW GLGLDQRIMP
     QYFRAAGYRT HMIGKWHLGF FTEHYIPTNR GFDTHIGYLG PYVDYWSYVS KMNSGTFEGY
     DMRQNQFVNY AANGTYATDY FTSAARDIIA QHGKSGQPML LVMNHLAPHA GNDDDPLQAP
     QETIDRFAYI GNRDRRTYAA MMSKLDDSVG AVYESLRANG MLDNSIIVFL SDNGGVTRGM
     HSNTGSNYPF RGQKHSPWEG AVRTAALIWS PLLKDTQRVS NQWFHISDWL PTLASAAGIA
     LGNSSFSDID GIDQWEALAY GTGNPRQRLM NNLDEIFGYT SYMENGFKYI NGTTLNGVND
     AWYGETDPLD QLPDDEQYLS SVMATRIARA GRLDEKLISY LRRHATVNCG NSIATKPCNP
     LVKPCLFDII NDPCEMHDIS DEYPKRLRGI RNRLELYRLR AAKPRNRPHD PEADPSKFGG
     VWNWWRTDPT KAASLQDEGD DSALPPPTHS LAKDTQLFVI IPIVVVGIIF VIGTLLYLSN
     KNIIKLCRRT KKQDSATTPS EIPTDASSPD GKAAADAAFS SKIYVISDRD MDSSSKQDQC
     SNSLEYDGWL NIALFHALDI DDPSKFTLRG NVTVTNRNTG LVSVAQEPLS LQDRNKLKRL
     AQENRLYRLE AHVTDSEGVT KFLTSSKACA LAKSQLTDVL WVSLDHTGTV TAVTQSVNNG
     NLNECADLSN SDVDVLDEFN TDVYVKHTEP APIPDTASFI QKMEREREAR ERGETKDNRS
     FFAKYWMYLV PVVILLLISA TNPEAGQQR
//