ID   A0A182WXU6_ANOQN        Unreviewed;      1437 AA.
AC   A0A182WXU6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=APAF-1 helical domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles quadriannulatus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA002356-PA, ECO:0000313|Proteomes:UP000076407};
RN   [1] {ECO:0000313|Proteomes:UP000076407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AQUA002356-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA002356-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   STRING; 34691.A0A182WXU6; -.
DR   EnsemblMetazoa; AQUA002356-RA; AQUA002356-PA; AQUA002356.
DR   EnsemblMetazoa; AQUA002356-RB; AQUA002356-PB; AQUA002356.
DR   VEuPathDB; VectorBase:AQUA002356; -.
DR   Proteomes; UP000076407; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd01671; CARD; 1.
DR   Gene3D; 1.25.40.370; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR041452; APAF1_C.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   Pfam; PF17908; APAF1_C; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703}.
FT   DOMAIN          139..356
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
FT   DOMAIN          452..574
FT                   /note="APAF-1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17908"
FT   REGION          1283..1309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1437 AA;  164569 MW;  0483063601D70411 CRC64;
     MNDLTALKSL RPMMRDLDVY DVLDEFQQQR VFNNDECMDI TNEPNEMFQI DLMFSLLEEK
     QQRDSQIVAR FMDALRLYYD WIVERWEQCR GAQTKEYNRY VAYRNESFMP SHESISVYRQ
     KLRWTMHKHL MSLRHGVAEH RYLFVCGIIG TGKQTLVCHA CEDYTVVTQM NYKIFYLDLA
     YCNTQEAILE LLEKLRVQLG DAVKQEERGN NYSYPSNKID YWKRTFTQAF ANELSESLLV
     LAHVNRPSLI KDFDFKCKTV VITKDTNVVN AVSESERFVV MLPQGFTEAE GLELFARALK
     KKNTMLPPEA TELCRACKYN PFLINLIALR MSEECKHEVP INWQQHIDNL ENFSMPRPER
     VSRTIASTLE QFSVEEQQRF RDLVIFRDNV PMSLRLLEMY WELDKDTTEA LLTRLERSGL
     LEKRVCKSKM FYIMQYICYN DIKLPPGSNM VNLHRRLLQN YSIRENLANR RELELTNVFP
     NDDYFHFHIA YHIEQAGEHD LFPELYQDFG FLEQKLRIAG LPNTVGDLRK YQEHIFPTVD
     DREVIIDSLI DFLMAAECLL SEDTRLLQRA LNFPGHIGHL AKQQVDRYKN RVWLRDVVHC
     FESSVIKLCH RPDKVRFQDA NHVFVSLANN DIQLWNLSVE YELPPMTFKG CDGDQIKDVQ
     RINQFLVALN RRGLIKVWST KNPPDRPDYR MWEASPREAE MTLTITGGFA CFSVLKRSGH
     TELIAISESG VLCVYKVYSS VFRTEKPDIK HPTNIRNAYL LQPFRDLDKP DGGAVRRCLF
     LVRSEDGTAR GIVFNMMSTS VESCFVDEQP PLNVYQLPEG FLFVSTHDVR LRPLESYGLG
     QAKTVYERKA CTNTCSVVTE DKRFLVLGTE RGISVVNIGD GAEVRRMNIS HSIVDLDVLM
     EDGMSQVLLA SISKDGEHTM NLYSLPLGPV SDQYQLEGTT AFLATLDNDP VQLNTVDRYC
     RLQQTLLHDE DGGVSHEKTF QNSAIDAPVL CLAKTRSMYY VGLENGKLLG MTQWHADPAV
     VHVVLELGTE ITYLECFRRV RQDDLEAMDI LVASGKGVCR ICVDERVELE LSETVRNCYL
     LYDRYLLLIG DRCSIQIYDF ENQTLELVQK EMERTYGAAV YGPPPRAALI LCTADGIVYH
     LGLHQAAIES FDLAPFDMLL TVKPPQSVSG SSSHSMPSDV DHHAATTVIC SCALSADGEF
     LAIGCHDGRI ILHLMEHNRQ LGVLESHQFP VSALYFSSWT DPSAPHILVS VGDQIVFWSV
     DYLYNNQPRK SVTSIRLSGR FNTRRTAPVP DGAHVSSPSE NRRSYGSNHS GFSTPVVGSP
     VSRSFLGERF EESSQWFDKR GSTVKPHLLS CIKLIGRAKR LIMNREFSKF LTMDDEGYIH
     YLRFYRPHVS HLLMPPPANF GMRSPTIVTA ATANTPMTAN GTNGGGGGVH PYITHLI
//