ID   A0A182X0C4_ANOQN        Unreviewed;       709 AA.
AC   A0A182X0C4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 2.
DT   22-FEB-2023, entry version 30.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
OS   Anopheles quadriannulatus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA003241-PA, ECO:0000313|Proteomes:UP000076407};
RN   [1] {ECO:0000313|Proteomes:UP000076407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AQUA003241-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA003241-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the kindlin family.
CC       {ECO:0000256|ARBA:ARBA00008052}.
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DR   AlphaFoldDB; A0A182X0C4; -.
DR   STRING; 34691.A0A182X0C4; -.
DR   EnsemblMetazoa; AQUA003241-RA; AQUA003241-PA; AQUA003241.
DR   VEuPathDB; VectorBase:AQUA003241; -.
DR   Proteomes; UP000076407; Unassembled WGS sequence.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13205; FERM_C_fermitin; 1.
DR   CDD; cd17095; FERM_F0_kindlins; 1.
DR   CDD; cd17096; FERM_F1_kindlins; 1.
DR   CDD; cd01237; PH_fermitin; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR037843; Kindlin/fermitin.
DR   InterPro; IPR040790; Kindlin_2_N.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037837; PH_Kindlin/fermitin.
DR   PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR   PANTHER; PTHR16160:SF13; FERMITIN 2-RELATED; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF18124; Kindlin_2_N; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889}.
FT   DOMAIN          402..509
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          207..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   709 AA;  80512 MW;  C2358ACDD364635B CRC64;
     MIHVGDNTWN LKVYITDLQV QKTLRVRGDL HIGGVMLRLV DPENPKDWSD HALWWPTRNQ
     WLTRTKSTLD QVGLHADALL HFTPMHKTLR VQMPDLRYLD CRVDFSIKTF GAVVALCKDL
     GIRHPEELSL CKPLEPMHLK KNYADLAKKK IPIEQNGNGR DYIHLAPDTN TFIPVAAHNL
     NGSNGSLDGP VHQGPFSCAP VPNAHFSTPK PALQSTPISS PTGTLRHGHG SGNSDSSSST
     GDGNENLAYS PYAPSPEARS RLLKPKTLVE RARMNISWLD SSLSIMEQGI REFETLCLRF
     KYYTFFDLNP KYDQVRINQL YEQAKWQLLN EEIDCTEEEM LMFGALQLQV NKQNEVPQAD
     SGIDTSSLDN AADDDVDAAL RELQITLEGP SNGANAGDIT HIPELTDYLR FLKPKKFTLK
     GYKRYWFTYK DLHLHLYKSR EDARANSAPQ VTINLRGCEV TPEVNLAQKK FNIKLEVPLE
     QSINSEMWIR CDNEEQYAKW MAACRLASKG RSLADSSYDS EVASIRSFLS MQKPAQAPAI
     NINPGEIDPS EYLAPRYAKK LKSKAMIRML EAHANVKDLS LIEAKLSYIR AWQSLPEFGV
     TLFVIKFDGH KKEELLGVAS NRIMKMDIAT GDHLKTWRYN TMKAWNVNWE IRCMMVQFQN
     ETVVFSCLSA DCKVIHEFIG GYIFMSMRSK ETNQTLNEEL FHKLTGGWN
//