ID A0A182X3H9_ANOQN Unreviewed; 3659 AA.
AC A0A182X3H9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Helicase ATP-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA004355-PA, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA004355-PA}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA004355-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 34691.A0A182X3H9; -.
DR EnsemblMetazoa; AQUA004355-RA; AQUA004355-PA; AQUA004355.
DR VEuPathDB; VectorBase:AQUA004355; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18069; DEXHc_ARIP4; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.20.120.850; SWI2/SNF2 ATPases, N-terminal domain; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR044574; ARIP4-like.
DR InterPro; IPR044573; ARIP4_DEXHc.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45797:SF1; HELICASE ARIP4; 1.
DR PANTHER; PTHR45797; RAD54-LIKE; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 855..1073
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 2039..2212
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1519..1762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1789..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1823..1929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1965..2012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2266..2285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2412..2438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2451..2552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2601..2635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2792..2992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3018..3108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3203..3260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3278..3370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3375..3394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3416..3458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3567..3586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3592..3630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 526..587
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 982..1009
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 141..155
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..752
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..789
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1519..1579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1593..1649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1660..1743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1974..2005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2266..2281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2451..2478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2496..2526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2527..2552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2601..2628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2792..2825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2844..2951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3065..3108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3203..3238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3246..3260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3375..3391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3601..3615
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3659 AA; 387488 MW; D8F91C9E292EC93F CRC64;
MDPNESHHPH SGAPGDGTGG RGPHSAAAAA GGASGGTGAP GSAAAAAAAA AAAAAAYHQQ
QYSQVPSHHL SSGYAAAMMD HHHHHHQMKD PYSHYHHHGR HPYADPYAAM HHGHGGAAYH
PSAHGPPPPP PSALGSMHSQ HSYPHHHHPH AHQNPYGHSY HHQPPGSYPG SQASASNAYH
HGGHPVHHAG HAASMGQYGG GQAQQYPGYG QLAGAADQLT PGGHYPGASS VSHHHNPSMG
AYRDDKEMLM GQQDHSGLGP NGSGSDASGM GGPPGGSTIP GNNPPSTAVP PGGGPGASSS
SGKRKIEILD NILIKKSKNT PSEGGMVAGG MHANSSHSNP YGQPVDPSLG AGGIAAMGAG
DSSKSSFQIS NLLDDKNAKQ QLPAAGGPYG ASDGAGGVVG QHHVHTAGHH EREKKGNESS
HYHHGSAPSG GSSGRKSSKA SKAGDSSKHD RSGASTSASG SEATAADQHQ QPQTSATQHM
DFDISEKLKE MGEISVKPVS KTDANTKSRA SELECNEEIS LEITKKDAAM RKVSNLRKNI
KEVMDDNQLD ASTLAAQRQE LERLARVQEQ QRIIREVQRQ LALERQTNKT EQKVMQFLQG
HASILKSQQP STSSTAASGS GSGGVASTTP IRVGYVKNPF ETRGRPPKNR QLLISTATTS
LLTTTTTTVA ASTTAATSTT NLTPSVSIAP VKASSVASAV TPVGPPSTTI SASASPSPSI
IPVRTFEEMV DSEEELEPEE EPEDEDEDSD GEVIALPEKK EIVTIDSSSD DDCIVLSDDD
EEPEDESDDD PQNSGLHVND AYNVPDEQGR VVINVGHADG EEDIFLAPQI ARIIKPHQIG
GVRFLFDNII ESIERYDSST GFGCILAHSM GLGKTLQLVC FCDIFLRHTS SKTVLIIMPI
NTLQNWLNEF NTWLPEDAEN SPLRNHGEVR PRNFRIHILN DSHKTLKSRS KVVLEWARNG
GVLLIGYEMY RLLSQKKMTK KKKKKKGVAV ELEEEKESTE EQRNMFDDIH EALVKPGPDL
VVCDEGHRIK NSHASISVAL KQIKSKRRVV LTGYPLQNNL LEYWCMVDFV RPNYLGTKTE
FSNMFERPIQ NGQCIDSTPQ DIKLMRYRAH VLHSLLLGFV QRRSHSVLQT SLPQKEEYVL
LIRMTEFQRK LYSVFMNEVV RTKAVPNPLK AFAVCCKIWN HPDVLYNFLK QSERDLDLEL
EEPEPPPVPG GVPGAVKPGE IPSTGITPAT SGTVTPMEVD SAVAAVPGAI PGTANTMEVS
PISSIVPSIG GPAKPGRKNA AVPKPAKPLA LKKDGTPRKP RTSKKATVAT NKSQAMGKDG
KMVPAATISP SNVNKDPAAM MMDTTPGAPG GSADFPKMEG SGADFGTEGG SSVKQEAGGA
MYPQQADGTQ YPGASGMGPS YPYQPYPGAG PMAPNHAYGS YGQGMNMMGG PDQSNVYGNT
YANAGANGQY GSGSNQAGGP GGATDPYNGG YGNNYYRNDY TSSYNQSSAY GATGNTSAGA
TGGYDHQSQY AYGANTSEGV ANSQYSSNGS EPGIQNPQSN SYWGDSANVN GSNTYYDQQQ
QQQQQQQQPT PTNDANGGTG TPYPGYGAGY EGANGGTQQQ QQPPISTDQN GSSGMFNFPN
AEQQSTAEAP STVNPQSQTT PSYDNFATPE TLPANGLPKW DPEQSSNGNH SAVGSDAELP
QSQTAESAVT EQEATAASTT TPTTDAPLVV PAQSSAETNE SNPDAAAITQ EQANAQYANQ
PSLEDLNDPV KPDLTGEKPP EIVGMDVKEI DKLDDELGIK QEIKQEKEVE DIKGEKETES
VQVKQEEQDS VVVKNEIKVE ENGEKIANDA CGDMPDKPAG EVKEEEKPTE SSEDVKPIKK
EELTEEVEIK QEEDKKPSTE GETIEPMEEK KVDEESVVDK KEEIEIPIEK KEAADQEAEE
AKAKEEVEKV VEEDVKLIVK DADGEAKLKD DTTQLEEGEV VVKVEEKESP TADKDPLSTT
STTTSTTTST TITTTTTTTT ATAGTKEGKG KDAKDEIPYE WAFELMKGYI PDLLENSPKM
DIFFCILEES IRLGDRLLVF SQSLLTLNLI ERFLQHNKIP GTENYWAKNI SYFRLDGSTV
AQEREKLINE FNSNPNVHLF LVSTRAGSLG INLVGANRVV VFDASWNPCH DTQAVCRVYR
YGQKKPCFVY RLVMDNCLEK KIYDRQINKQ GMSDRIVDEC NPDAHLSMKE ITSLCYDDGE
DGEMKDFSED KDKFIDIVMQ HLLESHSKKL TKAPFAHESL LIDRKEKKLS SAEKRQAQRG
YELEKQAATK PQYSYTSMGT TYRAIRTSDG SIIHRPVASV RPMQAGDANK TTTTGARPTR
WIAAEVWQRQ GMTAQEMTLP IDVVIPTSSA DKSNIVLKAG QKVMVLKSPK GIYMQLESGK
IIAIRTAFKV GQSKETPPAK GGIITTTPAA ATGRRTSNLS FGTAKASTTL LTSKNGAGGS
GGSAGDFSEG NSLSIASNSD DDEKSDSSML PLTINDDGDS EKESMSVDDY PDKPVSKKDG
TEVEQIVSER TTDTMMSSTS STSNSNSGMA MVPTTASTTT ATFTNASPVK SGNASASDTV
DKFPMIQSAY SLAPQAQSLA ANRAGSVGGP SHVSPSPSVV QPTATVTIDD DSPPMREKMV
YKPNLVERKT KASPSSLKNY RHKASKVQEI STTSTTVTPT SVGSVVAVVS STGTTTTTVA
SNSNVTNMHP GVATTKANEV PTINPASDAA SGMYNMASGT NAHNSSMYQP VMMMPNDKLS
ASHTTNNQST TVDAFGHGTG SVGGYPATSH LAQSGSKLPI TNPTPSMSSE TMASGLQQYP
GSHHTIPGGH QTGYGGHPPA TTATGSLAGK NHSQQQAAVG HASVTSPTAY NNSSTGASGS
TSKQHHSWMP YNSSAASGTG SSSSGNTMTP PGYGQLPQQQ QQQQQQLAQQ QHMQTHGSYS
QQQQQHHYQP MGGQMQHRMP HQPGHPHHLG MHQHQAAGGS VHPPPPAPQY ESSLNFLEKT
TSALINNQNQ SEFQASLSNI TRSPTPTDGY IDYNPKPAAA STKKGASGKS KTPKAPKNDY
NAAKKALNKR NNPSPYTHIS SSSASSSPSA SPAVMNHSQN TNTVPAPSTA GAGMYPSYHA
GAGASPAMTP AATAATSASV NPPSGLYYDQ YGQPINQHHQ QLTAGYGSGA GMGMGTPPTT
TATNNGHTLA SQPSTVAGYG NVPNPPVSSY AGPSYTSTSN STTSTATVRS NYYQTPGAPE
SGHISAGTGS VASQPSATGM LATETSPSAI GYAHQTPATV QPHHQHRPGS PSQTVPPHYT
QPHATAGTTS SRGGSSRGSS NAPPQQHQMH HMQQPQQQQQ QHHMQTQQHS THHQQQQQQQ
LVPQHTTPTA AAATVQPDYS MHSQSSASYG SAMGGAAPLT NPDIANTPSN TSTAANVYQQ
QHHLPSHQPQ HQHHQQQQQQ LPPAVSAPGS FLPYSSSSPA SATGYGVPSV AVASQNATTT
TSTVAAAVAS SAAGGPSGSS STAANGSAFH RPESAMTMGT AAPSAVAAPP ASTYDTPPTY
IPDANAPGAA AAAAAAAAYH QYHHAPYQSS QYHHHQPQGY YPPHAPPPSA YPYYPSSAGP
YGAGQPPPPP PGSGMVPADS QYHSYPPPPA VSAAAAAAAT ASNYNYPPYP SQPGVGQWQ
//
