ID A0A182XA41_ANOQN Unreviewed; 1358 AA.
AC A0A182XA41;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AQUA006680-PA};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA006680-PA, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA006680-PA}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA006680-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR STRING; 34691.A0A182XA41; -.
DR EnsemblMetazoa; AQUA006680-RA; AQUA006680-PA; AQUA006680.
DR VEuPathDB; VectorBase:AQUA006680; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 2.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR049135; TEP1_CUB2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR Pfam; PF21412; TEP1_CUB2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 457..589
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 666..757
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1263..1354
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1358 AA; 152085 MW; 794FE6EA769E787A CRC64;
MQKKRGGAQG AQKTASWNRF ISERVQAKMR HLASASLLVI TLLFNSVHGI LIVGPKHIRA
GQNYTVILSS FESNTNERNL LLQLDGLSAG GKKLLHLNQP ARVQPLSNSV ISFPLPDSLP
VGSYKLSIDG QNGFKFHWEA DLLLAASTTT ALVQLSKPIY KPGDVLQFRV IVLGGDLKPP
APSVTATVIV HDPQRNVIRR WTAVSLQLGV FEEQLQIGTV PLLGRYTITV TVTGANEIVS
KTFDVREYVL PAFEVAVQAR AVPLEKHQRL NLTLSARYYT GQPVRGVATV ELYLEDDKLD
QRRVVGVYGA TQLELPFNEH LSVYDDSQDV RVHVAFTQDE TNRTIYKEQR ITVYKLPYQL
ELVKEQPEFR AKVPFDCQLR VRYQDGTPAK GAAFEVKVEG AFTTDRRVAY TSDAAGVIKL
TLQPEASSES IDITVNAGSE ELLYERISKR EASKAFLQVK LDSDVKIGKS FKLKVTCNEE
LSFFMYYVVS RGAIVDSAFL QPKKVTEPFI EIKAADQMVP RSKVIVVTVA KNVVLCDFVD
IDFEDLRNNF DLQIDRTEIR PGDQLQLKMR GRPGAFVALA AYDKSLLQYS NNHDIFWEDV
WGVFDKFYSV ERNEFDLFHS LGLFARTMEH ITFDKANDQT ARDGSASSKN GPSNSQFSFR
TNFLESWLWK TDKIGSSGST TTKESVPDTI AAWHLTGFSI DPVYGLGIIK QPLQLTTVQP
FYIVPNMPYS IKRGELVELQ FIVFNNFPQK YKASVTLFSV DNQTEFVGRP ATETSYTKSI
EASPDTGVPV AFLIKARKLG EMTVRVDASI EPAKDSIESV IRVIPESLVK REMISRFFCH
NTYQNQTFVL GLDFDRKADA GTRKIDFILT PNILTSVMDN LESLLSVPTG CGEQNMMRLV
PIVLVLDYLT SIGSADKQLT AKAIGLLRAG YQNQMRYRQP DGSFGLWEKS GGAVFLTAFV
GKTLATAAKY ISEIEPSMVE QAFDWLAARQ HSTGRFDEVG PVFHWDMQGG LRQGIALTSF
VLIALLEQPK VATKHRAVIE KGIDYVTRTL GSIEDSYDLA IATYALLLQK HSSGERFLEK
LVGLSTVQQN GTERFWARDA HGIETTAYGL LSFVLAEKYV DGTSIMRWLV KQRYTPGSFP
RTQDTFVGLK ALTKLAEKIS PSRNDYSVQL RHAGRKEEFR VTSQDIGTLQ HAQQGVDETA
QLELHVAGIG FGLLQVVYEY GVDLRNFTAQ FVLELQKSVT NANHQLQLEV CSSFTPQLSD
GRSNMVLVEV NFPSGYTVEQ RGQPITGATK HNPIQKTEVR FGATSVVVYY NSMGPERNCF
TITAYRRQKV TLKRPAYVLV HDYYDPKLNA IKMYQVDD
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