ID   A0A182XDJ4_ANOQN        Unreviewed;       712 AA.
AC   A0A182XDJ4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=BHLH domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles quadriannulatus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA007895-PA, ECO:0000313|Proteomes:UP000076407};
RN   [1] {ECO:0000313|Proteomes:UP000076407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AQUA007895-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA007895-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A182XDJ4; -.
DR   STRING; 34691.A0A182XDJ4; -.
DR   EnsemblMetazoa; AQUA007895-RA; AQUA007895-PA; AQUA007895.
DR   VEuPathDB; VectorBase:AQUA007895; -.
DR   Proteomes; UP000076407; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd11410; bHLH_O_HES; 1.
DR   Gene3D; 6.10.250.980; -; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR   PANTHER; PTHR10985:SF77; TRANSCRIPTION FACTOR HES-1; 1.
DR   Pfam; PF07527; Hairy_orange; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00511; ORANGE; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF158457; Orange domain-like; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT   DOMAIN          50..112
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          123..165
FT                   /note="Orange"
FT                   /evidence="ECO:0000259|PROSITE:PS51054"
FT   REGION          33..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          548..712
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        584..598
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        661..676
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        677..704
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   712 AA;  75296 MW;  D45C5B7C8569133B CRC64;
     MTAKKDKDYK NHKHGSELSA TAISSKLDSH LASQTGTTAP GLIHAAQDPL KRTNKPLMEK
     RRRARINQSL AILKALILES TVKSKSGDGQ TKHSKLEKAD ILELTVRHFQ RHRNLDSPGI
     DKYRAGYTDC AREVARYLAT PEPPPLPSVP TLTDAGSKAR LLRHLDNCIA EIDTEICPKT
     VATGANGLPP VAASPGVGQD GKMLVDGVGA GGAAMYDGLK KTKDLLVEYG GAGGVVPQDT
     NPLDFSKTNR EIGRSPYSYR GSPTDLALLG PKSTSLLHQD ENNNRGTSGG TIGVHSAKPT
     GHHHPQATVS VANLEDMIHG SEIATTSAAA SSHSAAALNK MMLGHHQQHG KLSIEMASLK
     NCRIDPSAIK HEPGTAAALL ANGYSTASSA VSSPTPSPAG GILESDKDVS NHSEHSAVVP
     QPVAAGYPPQ SQVALLLPDH YIQLATALGL GSTPPMLDHH SAAAAAAAAA AAASLTSTDF
     ETLIEQNRRQ AAVLAHEKMT AEMLGSLHAL PDNVDEGYWE LYKKSLGIPD SISKLSLTDV
     RALMAKGMPP KVECGPPSSS VTPVPTVPPV TKMEIDDQQQ QQHHHHHQQH HHQQQHHAVH
     HTAGSVKSEP PSSGSPGLTS EPDVADGRAS ANGSRSPHSV KKESSSDGDV PMPAARPDPS
     HTPYLEERRS LSPRSVEDRR SPTSSNASGG SSERCNSTST VDGLHAPTWR PW
//