ID A0A182XKX5_ANOQN Unreviewed; 1855 AA.
AC A0A182XKX5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Protein son of sevenless {ECO:0008006|Google:ProtNLM};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA010515-PA, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA010515-PA}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA010515-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 34691.A0A182XKX5; -.
DR EnsemblMetazoa; AQUA010515-RA; AQUA010515-PA; AQUA010515.
DR VEuPathDB; VectorBase:AQUA010515; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 208..396
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 441..544
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 593..744
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 745..987
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 989..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1228..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1297..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1532..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1646..1694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1762..1855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1133..1164
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1228..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1346
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1429..1450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1555
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1580..1594
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1762..1826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1834..1855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1855 AA; 203083 MW; D226F422CD8AC95D CRC64;
MFSGSSHVSI TDAADYDFEN AENAAKWRGL FISSLRKVLE QVHPSLQARE DALLYVESLC
LRLLATLCAK PPPHTVMDVE DRIIRTFPTP IDRWALGEAR ETIDKSKKKK PVLPVDRVHT
LLQKEVLQYK IDSSVSLFLV AVLEYISADI LKLAGYYVKN IRHIEITRED IEVAMCADKV
LMDMFYQGES SNSMAPSPLP PTPRASLSYE EVVKELIHDE KQYQRDLHMI IRVFREELVK
IVKDPKELDL IFSNIIDIYE VSVTLLGSLE DVIEMSQEQT PPCIGSCFEE LAEAAEFDVY
AKYAKDITSV TAKEALANLL ARPEVVASSL MSAGHGFKEA VKFYLPKLLL GPIGHAQLYL
DYIKVLLQLS PSQEDKESFE QVQGLLKPLQ CELQSISSLL PKEYFTRVNS RARRQSAIEK
TRDLQNTVEH WDKDVGQCCN EFIREDTLAK LSSGKRQTER KVFLFDGLLV LCKARRQIVP
GNNYDYRQKE RFFMRKVEII DRPDTDELKH AFEISPREQQ SVVLITKNAQ HKNDWMADLI
MLNTKSMLER ILDSILLDIE KKHPLRLPSP DMYKFAVPDG PSNIVLEERE GTGVPLIKGA
TLCKLIERLT YHIYADPMFV RTFLTTYRSF CSPKELLQLL VERFDIPDPA VVYDPAAEKE
LAGDTDKFHK NSQREDWKRY KKEYVQPVQF RVLNVLRHWV DHHFYDFERD GELLESLERF
LETVRGKSMR KWVDSVMKIV QRKNESEDNH RQITFAFGHS PPAIEHHLPL NGENEFNLLM
LHPLELARQL TLLEFEMYKN FTRWIEKSII EAENFEERVA MASRAIEVMM VLQDLNNFNG
VLSIVSAFQG AAVHRLKLTL EDIPKRHQQV LAECRELNNS HFKKYQEKLR SINPPCVPFF
GMYLTNILHI EEGNPDFLPN TELINFSKRR RVAEITGEIQ QYQNQPYCLK VDPSIRNFLE
NLDPFKGMSI TEIQNYLYEE SKRIEPKNCR QPLKFPKKWP DISLKSPGIK PSSRRNNSSA
NSSMTLPGTL PYSKTSLLAN SDTGEQSPPA SSSSSVHDYS IFASVNIHSS SSGTSSLSSL
YYQQQQQHLQ QQLQQQQQHH SGFYHGQQQQ QQQQGGGVVA GSSSGSSQYS HHGSAHHHPH
QQQYLPHHHP HHHHHHHHHP HHYHPSFSQS IANLTTAGGD SQMAPEIPRR SDSIILTNTN
QLLAGSGCLS ESSGGSYNGG KLLPSPRYPS ASMTTLPSSS SCSAAGTSGG GTGGMAVGAS
SYSIGGSLYS GSSSEASGYG TASSVTSSSA ASIVSMSHND ATVQQQQQQG SAVVIPHPDI
PPAISPRTDK PQPLHPPPPP PPSLQHAASA SPGATAGSGS SIAGSSILAN MAAVGTSIAN
STSSNFRHSA SNSIKNQNCD FTYTIPGGGG GPMGSSASGA PPPPTNSSGR PSSCEHSPVY
PSSPKIQLQH NHPTAGAALP PVCPHHHHHA AHHHHTDAAA AADGGGPAAN SIQYNSSVSP
SASSHHPCHL CAGGVDAGGS LSYNADIGPT PISPHVNVPN THNVLPPPAP PLPPRAKRKE
SSMDSTQSSQ MRQAPDAPTL PPRDVSPPPL PPRIYTQSSH YQFGVASQTG TTLLLNYTQS
PGVCGGGGVA GTGGSSSFPM DSSNWNHSSF HAKDESTSSS SSSSTLTRDN LNQHNQHSVG
GTTASSSSQN SSSMEQRLLM LPHTSTIMMR RNSAMDRAAK ENIPNIATSS SLSGLSTIAG
GSAGGGGVGG ANVAPGVGVG GSGSTMNSSG GPSVSGSLGS SGASVGSSPS AVKNKSVQNS
PISGQAQQPN VLCRRASTNI SPRFSPGETT PKLPPKPKQN SISSDRTMFP YPSTN
//