ID A0A182XLK2_ANOQN Unreviewed; 140 AA.
AC A0A182XLK2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC9 {ECO:0000256|ARBA:ARBA00016672};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA010747-PA, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA010747-PA}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA010747-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Accessory protein for the calcitonin gene-related peptide
CC (CGRP) receptor. It modulates CGRP responsiveness in a variety of
CC tissues. {ECO:0000256|ARBA:ARBA00043924}.
CC -!- SUBUNIT: Component of the RNA polymerase III complex consisting of 17
CC subunits: a ten-subunit horseshoe-shaped catalytic core composed of
CC POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10,
CC POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and
CC POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and
CC CRCP/RPC9, protruding from the core and functioning primarily in
CC transcription initiation; and additional subunits homologous to general
CC transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-
CC POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription
CC initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both
CC transcription initiation and termination.
CC {ECO:0000256|ARBA:ARBA00044007}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC9 RNA polymerase subunit
CC family. {ECO:0000256|ARBA:ARBA00006898}.
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DR AlphaFoldDB; A0A182XLK2; -.
DR STRING; 34691.A0A182XLK2; -.
DR EnsemblMetazoa; AQUA010747-RA; AQUA010747-PA; AQUA010747.
DR VEuPathDB; VectorBase:AQUA010747; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006384; P:transcription initiation at RNA polymerase III promoter; IEA:InterPro.
DR Gene3D; 1.20.1250.40; -; 1.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core.
DR InterPro; IPR005574; Rpb4/RPC9.
DR InterPro; IPR038324; Rpb4/RPC9_sf.
DR InterPro; IPR038846; RPC9.
DR PANTHER; PTHR15561; CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN; 1.
DR PANTHER; PTHR15561:SF0; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9; 1.
DR Pfam; PF03874; RNA_pol_Rpb4; 1.
DR SMART; SM00657; RPOL4c; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 1..120
FT /note="RNA polymerase Rpb4/RPC9 core"
FT /evidence="ECO:0000259|SMART:SM00657"
FT REGION 111..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 140 AA; 15560 MW; E66DB95E9FA44695 CRC64;
MEIVNPNAAI LTNYEVMTAL KDMKNSKKKY GLRNLATITY ETVQYLEDTP CKEQSTAGII
DFLQAMKEFN LTKNECLMMV NDPPSSPLHI QLMIEDSDER LTEEQVTRIL EQTAKLRTPA
TPAAGTPGTT TTETTGQADS
//
