ID   A0A182XLT9_ANOQN        Unreviewed;       881 AA.
AC   A0A182XLT9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   13-SEP-2023, entry version 27.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
OS   Anopheles quadriannulatus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA010834-PA, ECO:0000313|Proteomes:UP000076407};
RN   [1] {ECO:0000313|Proteomes:UP000076407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AQUA010834-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA010834-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC       subfamily. {ECO:0000256|ARBA:ARBA00010907}.
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DR   AlphaFoldDB; A0A182XLT9; -.
DR   STRING; 34691.A0A182XLT9; -.
DR   EnsemblMetazoa; AQUA010834-RA; AQUA010834-PA; AQUA010834.
DR   VEuPathDB; VectorBase:AQUA010834; -.
DR   Proteomes; UP000076407; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00185; ARM; 3.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
FT   DOMAIN          22..102
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          410..447
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   881 AA;  98336 MW;  BE748FCB89BE68EE CRC64;
     MMHIVQILEK TVSPDQDELL AAKNFLEQAA STNLADFLRA LSDVLVYPGN STVARMAAGL
     QLKNHLTSKD QTIKQQYQDR WRAFPEDVKE YIRKNILGTL GTEESRPSSA AQCVAYVAVA
     DLPVHQWPDL MQKLVDNVVN EKSTEALRES TLEAIGYICQ DINSEILEHQ SNQILTAIIH
     GMRKSEPSNH VRLAATNALH NSLEFTKANF EETAERNYIM EVVCEATQST DTQICVAALQ
     CLVRILTLYY QHMEAYMAQA LFPITLEAMK SENEQIALQG IEFWSNVSDE EIDLAIEAQE
     ASETGRLPNR VSKYYARGAL QYLVPVLMEK LTHQEEFDDE DDWNPAKSAG VCLMLLATCC
     GEEIVPHVLP FVNANIKSTN WRFRDAAVMV FGSILSALET DRLKPMLEQA MPTLIELMYD
     ESVIVRDTCA WTFGRICEVI PEVAIKEVYL EPLLKALLNG LKAEPRVATN VCWAFTGLSD
     AAYEAVNIED DPPQTYCLSK YFDFIITSLL EATDRPDGGQ GNLRSSAYEA LMEMVKNSPQ
     DCYVSVQRTT MVILERINHV LQMESHISSH SDRHQFNDLQ SLLCASLQSV LRKVDAKDAP
     QISDAIMVAL LTMFSSSSGK VCGVQEDALM AVSTLVDLLG EEFIKYMDAF KEYLYMGLKS
     HQEYQVCCTA VGLAGDICRG LKSKILPYCD DIMTLLLQNL SNPNLHRSVK PQILTVFGDM
     ALGIGPDFKK YLNVVLPMLA AATQVQIDQH DYDMIDYLNE LRESVLEAYT GIVQGLKGSD
     KQPLEDVNAL LPHVPFIVSY IVSIAKDSEL SDGNIAIAAG LIGDMCGAFG PMMLQFVEDP
     SITELLNDGK NSRTNRTKTL AGWAMREIKR VKNLPVNSSW K
//