ID   A0A182XM97_ANOQN        Unreviewed;       904 AA.
AC   A0A182XM97;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|SMART:SM00913};
OS   Anopheles quadriannulatus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA010993-PA, ECO:0000313|Proteomes:UP000076407};
RN   [1] {ECO:0000313|EnsemblMetazoa:AQUA010993-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA010993-PA};
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000076407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:AQUA010993-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA010993-PA};
RG   VectorBase;
RL   Submitted (OCT-2016) to UniProtKB.
RN   [4] {ECO:0000313|EnsemblMetazoa:AQUA010993-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA010993-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR   AlphaFoldDB; A0A182XM97; -.
DR   STRING; 34691.A0A182XM97; -.
DR   EnsemblMetazoa; AQUA010993-RA; AQUA010993-PA; AQUA010993.
DR   VEuPathDB; VectorBase:AQUA010993; -.
DR   Proteomes; UP000076407; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          31..99
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00913"
FT   REGION          329..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..377
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   904 AA;  102128 MW;  381BF485063B7613 CRC64;
     MSWEPQPDGL SQIITLLKQS QSTDNMVQRA VQLKLEELNQ YPDFNNYLIY VLTKLTSEDE
     PTRSLSGLIL KNNIRIHGTE LQPAIIEYIK QECLMALGDP SPLIRATAGI LITTIANKGG
     LQNWPELLPT LCDMLDSQDY SVCEGAFGAL QKICEDSADV LDSSALNRPL NIMIPKFLQF
     FRHSSPKIRS NAIACINQFI INRTQALMVH IDTFIENLFH LSSDDDREVR KNVCRGLVML
     LDVRMDRLMP HMNSIIEYML IRTQDSDETS LEACEFWLTL AEQSICKEVL TPHLPRLVPV
     LVRGMKYSDI DIIILKGDVE EDEMIPDREE DIKPRFHKSR THTQKPSLGG GASGADGAVR
     AMEGNDDDED IDDPYDEMDD DSNLSDWNLR KCSAAALDVL ANVFKDDFLP ILLPILKETL
     FHEEWVIKES GILALGAIAE GCMNGMVPHL PELIPYLIVC LSDKKALVRS ITCWTLSRYA
     HWVVSQPHDQ YLKPLMKELL KRILDANKRV QEAACSAFAT LEEEACTELV PYLGFILDTL
     VFAFRKYQHK NLLILYDAIG TLADSVGHHL NKPEYISMLM PPLIEKWNNL KDEDKDLFPL
     LECLSSVATA LHSGFLPYSE PVYRRCISLI QQTLNQDLAS TTSPGQFEQP DKDFMIVALD
     LLSGLAEGLD CYIESLVSSS NIMQLLYQCM QDSMPEVRQS SFALLGDLTK ACFQHVHPHI
     ADFLPILGHN LNPEYISVCN NATWAIGEIS IKLMEDTKPY IPMVLAPLIE IINNTNTPKT
     LLENTAITIG RLGLVCPVEV APSLQQFVRQ WCSSLRNIRD NEEKDSAFRG MCQMITVNPV
     GVVPDFIFFC DAAASWMTPK KDLHEMLQKI LHGFKMQVGE ENWARFVEQF PPQLSERLAV
     MYSI
//