ID   A0A182XNB0_ANOQN        Unreviewed;       722 AA.
AC   A0A182XNB0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS   Anopheles quadriannulatus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA011360-PA, ECO:0000313|Proteomes:UP000076407};
RN   [1] {ECO:0000313|Proteomes:UP000076407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AQUA011360-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA011360-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A182XNB0; -.
DR   STRING; 34691.A0A182XNB0; -.
DR   EnsemblMetazoa; AQUA011360-RA; AQUA011360-PA; AQUA011360.
DR   VEuPathDB; VectorBase:AQUA011360; -.
DR   Proteomes; UP000076407; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF74; ANOCTAMIN; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        284..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        314..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        385..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        422..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        470..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        583..606
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        634..658
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        673..693
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          273..708
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          72..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   722 AA;  84099 MW;  38C80A5C4D30559E CRC64;
     MDDIKENLIP NLHFAENDEE ELAEEIGLPA RPTIPSLLQR NSQINLLEKM DHSGEQNKLN
     ELRNRKGTVR INQPKVTRQD KARPPDDEQE PFGESLMLLE FGENAPVEAI QWIMDKIRGR
     RVDGGMELMV RKEPLSKDSK TIIFHLSATH MKLLEIADDM GFMKRTKSGI IRNFNVACLD
     EFFYDESMAL EDILTPADRQ IIVKHALETI KAADDEHRIP GTKIILYHGQ SIIQAAQSAE
     LITNLYSLHD KRTLKELRHR WIKPTRVQPI DEIRDYFGES VGMYFSFLGF YTYALVVPTV
     FGFLQLGLSE ETETVPFFCV FYVVWMKVFL ELWKRKSSSH AYRWGTITMT NLDEPRPGYY
     GKLARDPITG KWTPQYPKWK TYVQMYCVTA PIIMLCMGIA AFVTIFQFYV EAYLAELFGP
     DAYILYLPSV VNAIYIAVST LAYDRLATYL TDKENHRTQS QYERHRVNKL IVLEFVNNFL
     CLFYIAFILQ DMKMLKTQLM MQLIVLQFLQ NVFENLYPYL KKKVGLKIVR LFVKSNYEKL
     KLAHESYDEM GLRSLDEDDP RVVQNRKETI LEEYNTYDDY LELYIQFGYV VLFSSVAPLT
     AFWAILNNVI EIRLDAYKLC SFFKRPFARR TKNIGAWQLA FETLAVISIL TNCGILYLSP
     HMRELGAGLT REAYTLTFLI IEHVLLGLTW FIYKAIPDTP HWVRVALAKA EHESRQALKR
     EE
//