ID A0A182XV86_ANOST Unreviewed; 660 AA.
AC A0A182XV86;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Peptidase S1 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI00122-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI00122-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI00122-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.
CC {ECO:0000256|ARBA:ARBA00024195}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; A0A182XV86; -.
DR STRING; 30069.A0A182XV86; -.
DR EnsemblMetazoa; ASTEI00122-RA; ASTEI00122-PA; ASTEI00122.
DR VEuPathDB; VectorBase:ASTE003061; -.
DR VEuPathDB; VectorBase:ASTEI00122; -.
DR VEuPathDB; VectorBase:ASTEI20_042246; -.
DR OMA; NEIKCPS; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00033; CCP; 1.
DR CDD; cd00112; LDLa; 4.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00192; LDLa; 4.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 4.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 4.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50923; SUSHI; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT DISULFID 39..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 46..64
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 80..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 87..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 129..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 136..154
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 170..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 177..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 660 AA; 72672 MW; 3999DE07BD104335 CRC64;
MIRKRRKWPA AGLLCVFVLV TASCAASAAS FTRDRRKVCN YYEWKCSSGQ CIESHQQCDG
VIDCKDGSDE TSKSCAFIRC PSYAFRCQYG ACVDGNALCN GVRECADHSD EHAHCPGNSG
MILATHGNCS NTEFACHSSE CIPADQVCDG QEDCPDGTDE TQQLCSLVFC PSFSFRCSYG
ACIGGYSKCD GVIDCRDGSD EDELLCGKPF PSTTPRLTTV MTSTTTTTST TTPAPVTGPP
GSCLVPAAPT NGRIVLDESA QNVLIKAGEF IENYNSVYVA CGDKYTLKGA ATIVCLDGEW
LEPFPVCEKY CSEIPINGIT IEPFCEYQRR QITCKRPLPP TTRVRIGCRV GYQKPLEPVN
ETLTCVDGSW DSAVFRCEPV CGTPTPDAEA YIIGGRNVSI AEVPWHMAIY KNLNEDTLSE
LRSSDWQYVC GGSILTERLV LTAAHCFWAT EGFFPKRFFR LVAGKYRREI SAIEALPPQF
FQIHEILHQP QYQDFSGYYN LDIAIVVLSD FISFRTYIRP ICLERNLRTE SEKRIKPNSV
GRVAGWGFTT TTGNLSSVLK VIDISTVDYV TCREFSPIAY RPFLTGDKFC AGNPKTWDRG
GGFALGKEVA GDTVYYLYGL VSSAPRASDG GCDSNKYVAF TEVQNYIPMI LDAEGRYPVI
//
