ID A0A182XW42_ANOST Unreviewed; 2171 AA.
AC A0A182XW42;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI00428-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI00428-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI00428-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000256|ARBA:ARBA00008335}.
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DR STRING; 30069.A0A182XW42; -.
DR EnsemblMetazoa; ASTEI00428-RA; ASTEI00428-PA; ASTEI00428.
DR VEuPathDB; VectorBase:ASTE004212; -.
DR VEuPathDB; VectorBase:ASTE011675; -.
DR VEuPathDB; VectorBase:ASTEI00428; -.
DR VEuPathDB; VectorBase:ASTEI20_040229; -.
DR VEuPathDB; VectorBase:ASTEI20_045138; -.
DR VEuPathDB; VectorBase:ASTEI20_045524; -.
DR OMA; YHADGFE; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 8.
DR Gene3D; 2.60.40.60; Cadherins; 9.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23511:SF36; EG:BACR7A4.13 PROTEIN-RELATED; 1.
DR PANTHER; PTHR23511; SYNAPTIC VESICLE GLYCOPROTEIN 2; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 8.
DR SUPFAM; SSF49313; Cadherin-like; 7.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 8.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 48..520
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 804..890
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 891..1010
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1011..1132
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1319..1423
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1425..1549
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1563..1675
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1695..1790
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1791..1903
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 2171 AA; 244078 MW; 53B06961FB3D6CDB CRC64;
MESTKDKHSK VIEINVPPGG TVGDGVNAPA DFETAIATTG YGRFNYLLLL VAMPCCMTTV
FETTTMSYVL PSAECDLNLS LADKGMLNAI TYTGMITSAF LWGFLSDTYG RKRLLVVGYL
LDSTFNVLCA LSQNMVAIMV FKFMGGFVIC GPFAVLMAYL SEFHSLQHRS RVMIVLGVFY
SAANMLLPAM AWLIIPQPWN LVFGDGVLEL HSWQIFLAVS CLPGVLSGII VMFLPESPKF
LMSKGQNERA MAIFRRLYAI NTRSQQEFPI RELVDELRQG SSSEPTSGKQ PSSDKATHPA
PSGVGEGFRQ LGIMFRKPHL KNACLAYGIQ FGILLGLNTF RLWVPQLFTI IEEFEHEQHL
LPADGTMAPA YGASMAAGQA TLCEMLAYKV NKTEQQHQQW LEYEVSRALH GPDPVAMEPL
DDVLQCTATT EGRVYLYSLI IGCVGIGAYA VTTVMINSIG NRNILTYGLL LAGSCGTALY
WARSSLVTLI LSSCYITICS IASTALVGAV VSMFPTSMRS WSALLWSVLL MMLLPTVIEV
HCQQWSDPKF DTGNTENISL AAFDDTLLQQ DVWMVEEIQP PFVLVCLNYQ GPPEPTIRQS
PANLEAELRR ANDGRWCIYI NRRQDYEVDK RSNIILLVVE NPAIPYTLLV TLVNVLDNAP
VMTAEGNCEI EEQRNDFVSD CLFNVYHADG FEVNGIGNSS TNELSFAIDD ASGAGEHFEY
VVAAKTHPQP NYNKQYNLKV KKALDYTEKA IFNFITTVYD LDRTHSFSMS TIVQVRNVDS
RPPIFSRPFT TERILEKEMF QTLVIAIDRD TGLNKPICYE LTTNEPKYQK YFEIGQSDGL
LTVHPIDRDA EQNELYSFAI VAYKCHNKLL NTTSEGAIIL EDKNDNFPEI AMSPVELEFW
ENTIMELDFK QFTINDRDLG EHARYEVRLA ETVSGQQQPT TSFTIIPESG YQLVSFTINI
INAAKLDYEL PERQTFLLHV TAQEPIEPTH QNTQTITIRL RNWNDEVPKF GQENYQTSVL
ETIGADVLLA SVAITDRDID DSIKLTVLGR LSESLEVVSL PVGTDPLSGD PMYQFELKTK
RADIFDYDVA QEVIVQLQGE DTLRTERNEP IHQIFSQLTI TVLDVNNKPP QITLPRGTMH
ILENSVAESE VIIGEEEVAK IIGTDPDTEA ELVFSIDWSK TVVAIQIDDE NDNKPFFDEA
TLQVVRSVRE QSDSGVTIGN IIAYDIDGPG NNEMTFSMEP LDPAHKEWME IDQNGIIRVK
AAQSIDCDIP PIDFVLQNVT VSDWKWGNWH VFQIDLMDTN NKQPYHEPLP DDGQVYKFEK
IPSNTEIVLV EGKDLDRDEP YRTVSYEINY RDFPQLQRYF EVNSTGRVYV KENNDLLDRD
GGLESITINI VMVDNAGGFG IQNRVSTNIR LTLLDINDHY PELPELASEE LEISEDFKQG
HIIREKFVAT DRDDKETPNA KVNYYMRQIL PARETDIFFL EYVDEYSTSL KVAQDLKGYH
GTWTLKVEAC DRGIEYDPII ELPEPPESKC STRDYELVVT PFNYNSPTII YPTRNAQIRL
KYESLKNGSP LVDTNGSNLP DFVAVDDDGG IYGDVTFSLQ STNDNDRDHE VFRMDKLDAK
TGRLVLENEQ AVQPFPKNYS ITVIARDGGD KQTETTIFIV FINMTGEPAF LQPTFDTDFT
ENEEGLDERR QLPFAEDPKN AGLPPGAQTN VFYFIDQKYG NASHLFALDP ETNVLRLDQL
LDREEIPSHE IRIVATNNEN GPPATLVDSS PSLLVVRIKV NDVNDNPPVF QQRFYAAGIT
TNDRVQKPLF RVYAEDPDED EIIRYEIVSG TEQAVGENLP TDALPFRLNP STGELTLVQK
VQPNQKGYYQ FTIIAFDNDD THNDTVQAKV YIVSESNRVT FVFLNSVEEI DQPDVREFLA
TQLTASYGME CNIDDIDQAF SERQEGSSSS ALTDVRTHFI QDNQAVEASR IQQRSSNRTF
VTELKATLRI RNLSLQDVPP TPESLTEADE TLQIILIVVS AALAVLCVIL FVAFFIKIRS
LNRQLKALSA TDFGSISSEL NGKPTRNVPT TNIFSIEGSN PVLNDNEFGR MGGGGVYDDL
SLQSEESDFN DMDRDIFSPK RKESLNPAFL EHLRQRSLNP MANGMDKSIE VVEGPTHKKL
DETDDELSHR F
//
