ID A0A182XYY9_ANOST Unreviewed; 1432 AA.
AC A0A182XYY9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Phosphatidylinositol 4-kinase beta {ECO:0000256|ARBA:ARBA00039877};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI01425-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI01425-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI01425-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00036767};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19878;
CC Evidence={ECO:0000256|ARBA:ARBA00036767};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}. Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004450}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00037860}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037860}.
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DR STRING; 30069.A0A182XYY9; -.
DR EnsemblMetazoa; ASTEI01425-RA; ASTEI01425-PA; ASTEI01425.
DR VEuPathDB; VectorBase:ASTE002382; -.
DR VEuPathDB; VectorBase:ASTEI01425; -.
DR VEuPathDB; VectorBase:ASTEI20_044146; -.
DR OMA; SMGIMLP; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1149..1417
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1432 AA; 155938 MW; 86D866AA11B650E7 CRC64;
MGILLPPVSQ VTNNRINMTQ HHRNRSLDSA LQRIPEVEVS SPSAESENTL HCTNGILSGT
MCSKIIQSSS TNPTNTPSNS GRGITSMSIA GTTRSDSAAG TETVVIASSA SATNSTTHHH
QPGRQQIGRK AGDLLEQGTV LRALKSSHST DAETIVNSIV KDSDSKKRED LTSLGSDDSG
IICGSEPDHT SLTRIRRSRE SLDSGEIDPS EEECIEILET TSMEEEYRML QSDLCFYPTT
SMDRTAKEDG SDSDSRPLDN CIELQQQQQQ QQHSQKQIEA GVNGPVSDKV RYRQQNMTRA
AIMLEKLFVP IHFEDGEGGV APVVGANLGN EEDELLTHPD AATPIVGEGK SLTTPTNAMT
MTTVPFAQQP AASTNVPSTA VSPSETKPAL SDPPKTDQKN EVMFRNFFGA TKNAIFRTAQ
SIIDNHEKKH AKQKQEKQAA THTAPEEAGT ATTGSGGAGV GATASGASSS TTVKSPTELL
RKREFGSMFA RSSSSSKHHH QAPQQTSNSS NTTSNSSSSS SSSSSNSATT PTTTTTTTSA
SMEFETTATC TDSGNSQLNI PKTSLSKSSS TASLKVVPGV AVAATPSSSS SSSSNTTSTA
TMHCTGSGPR DESQIRTERT GQSGLLRFFE SPVFNIHFAV HYLFYSKEPG VLSFIGNKIF
SFPNGEVDLY IPQLIVMYMQ IEELSEVLDP YLVYRCRQSV DFSLKCVWLL EAYNFNTEML
SGAGNSVRKH LSLLRELYPK RERVKLAAAQ LTSSAAPNPA STGGEALGTT SDPLTLQAHP
ALSAVRKTHH RSQSDATGMM GLLAQHHHAH HAPLPGVPGP SNRTPVCLGD LSTGRAFDNG
CVCFESVRGT VNDLLGQQTV CSCGAPKLAP EKEFMKALID IGKMLTCLQT KIEKTSRLRI
LLNLINKNLP ARVWLPLHTE TPHHVVRITE EKTAVLNSKD KTPYIIYVEV VEVQDIYTSP
VIPKLMPTLR HTKSEERLDS SISASALNST DESNPSKTEQ TTAGSSCQPA SEETATGSSS
AAPPNVPLPA AVAASLATSR SRHSKLSECS ADIGAGGGSM MELGLTEDDV WSQEDDEITA
QYLSLTKMSS DRDAISQFSV DSYDSRDHHT PALFNIGEVK KRHCANLNSE NAKPFSNDPS
DPSAAALKEP WHEKEKQIRD SSPYGHLQSW RLLSAIVKCG DDLRQELMAT QLLQMFKLIW
EEEKVGLWVR PYRIVCLSND SGLIETIVNT VSLHQIKKNS NKSLKDYFID EFGDVETVAF
RVAQRNFMHS CAAYCLISYL LQVKDRHNGN ILLHSDGHLI HIDFGFILSI SPKNLGFEQS
PFKLTPEFVD VMGGPESELY CEFKYLLLDG LKAARKHMDR IINIVEIMRS SSQLPCFKNG
CSGTVRNLRN RFHMNLTEQE LERKVEQLIQ DSLNSLSTKL YDGYQYITNG IL
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