ID   A0A182XZ03_ANOST        Unreviewed;       964 AA.
AC   A0A182XZ03;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   13-SEP-2023, entry version 33.
DE   RecName: Full=Vinculin {ECO:0000256|ARBA:ARBA00014125};
OS   Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI01439-PA, ECO:0000313|Proteomes:UP000076408};
RN   [1] {ECO:0000313|Proteomes:UP000076408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX   PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA   Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA   Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA   Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA   George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA   Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA   Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA   Sharakhov I.V., Tu Z.;
RT   "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT   stephensi.";
RL   Genome Biol. 15:459-459(2014).
RN   [2] {ECO:0000313|EnsemblMetazoa:ASTEI01439-PA}
RP   IDENTIFICATION.
RC   STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI01439-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC       {ECO:0000256|ARBA:ARBA00004536}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC       {ECO:0000256|ARBA:ARBA00008376}.
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DR   AlphaFoldDB; A0A182XZ03; -.
DR   STRING; 30069.A0A182XZ03; -.
DR   EnsemblMetazoa; ASTEI01439-RA; ASTEI01439-PA; ASTEI01439.
DR   VEuPathDB; VectorBase:ASTE002366; -.
DR   VEuPathDB; VectorBase:ASTEI01439; -.
DR   VEuPathDB; VectorBase:ASTEI20_033047; -.
DR   OMA; ANNLCEL; -.
DR   Proteomes; UP000076408; Unassembled WGS sequence.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR   Gene3D; 1.20.120.810; Vinculin, Vh2 four-helix bundle; 1.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR017997; Vinculin.
DR   InterPro; IPR006077; Vinculin/catenin.
DR   InterPro; IPR000633; Vinculin_CS.
DR   PANTHER; PTHR46180; VINCULIN; 1.
DR   PANTHER; PTHR46180:SF1; VINCULIN; 1.
DR   Pfam; PF01044; Vinculin; 1.
DR   PRINTS; PR00806; VINCULIN.
DR   SUPFAM; SSF47220; alpha-catenin/vinculin-like; 6.
DR   PROSITE; PS00664; VINCULIN_2; 2.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ   SEQUENCE   964 AA;  106711 MW;  DA6F98C833A872A7 CRC64;
     MNHSKVKRPL GNTLEYVYAR ANVSRLVILH EEAEDGNAMP DLGKPVQAVS LAVTNLVRVG
     RETIQNSDDD ILKQDMPASL TRVETAAQLL EEASLMLRSD PFSGPARKKL IEGSRGILQG
     TSSLLLCFDE SEVRKIVREC KRVLDYLAVS EVIDSMEDLV QFLKDLSPCL SKVTHQVGAR
     EKELTHQVHS EILVRCLEQL KILAPILICS MKVYILIAEQ SGKGSEEAAE NRNYLASRMS
     EELQEIIRVL QLTTYDEDQS ELDNLTVLKK IHNAINNKLE AANEWLRNPY ALRGGVGEKA
     LRQIVENGLK VADRCLPQDS HILRKLAGDI TAMTNTLCDL RQDGKGTTPH ADNIARDIRD
     KLGSLEQSVL NAIMGVDKAG LQQTAHTVQG RLEQACRWLQ NPARDDRGLG VRAIALIVDE
     GRRVADGLGG HQKAEMGQLC DEVEQLAHDF SQLCANGLGH TPQAQELARR LNEKLHGLKK
     QIQDAVVNRV VEDFIDISTP LKQFMEAVAQ PEGTPGREQN FNQKSNRLQA FSNRASKTSR
     MVAAGGSGGN KKLAEGLLAS ANQIDSLTPQ LVSAGRIRMN YPTSKAAEEH LNNLKQQYAD
     TILRMRTLCD QATDPADFIE ASEKQMQKHS ILCDDAIRTR QPQKMVDNTS SVARLANRVL
     LVAKQEADNS EDPEYIGRLN GASDQLQASI SPMVQEAKNV SSNINDPVAA SNWREANRAL
     LQSVRNVRGA VTHAPAVPEM PDLSQLQLNE AVPPPRPPLP RENVPPMRPP PPVAETDDED
     DVFQAGSMPH ANQPILMAAH GLHQEVRQWS SKDNEIIAAA KRMAVLMARL SELVRADSKG
     SKRELIATAK QIAEASEDVT RLAKQLARQC TDKRIRTNLL QVCERIPTIG TQLKILSTVK
     ATMLGAQGSE EDREATEMLV GNAQNLMQSV KETVRAAEGA SIKIRSDQTN QRLRWVRRQP
     WYQY
//