ID A0A182Y1S9_ANOST Unreviewed; 2116 AA.
AC A0A182Y1S9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:ASTEI02415-PA};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI02415-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI02415-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI02415-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: May be involved in the metabolism of insect hormones and in
CC the breakdown of synthetic insecticides.
CC {ECO:0000256|ARBA:ARBA00003690}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004174}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
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DR STRING; 30069.A0A182Y1S9; -.
DR EnsemblMetazoa; ASTEI02415-RA; ASTEI02415-PA; ASTEI02415.
DR VEuPathDB; VectorBase:ASTE001565; -.
DR VEuPathDB; VectorBase:ASTE015849; -.
DR VEuPathDB; VectorBase:ASTE016039; -.
DR VEuPathDB; VectorBase:ASTE016040; -.
DR VEuPathDB; VectorBase:ASTEI02415; -.
DR VEuPathDB; VectorBase:ASTEI20_031005; -.
DR VEuPathDB; VectorBase:ASTEI20_039436; -.
DR VEuPathDB; VectorBase:ASTEI20_044670; -.
DR OMA; ANIMKQR; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11056; CYP6-like; 4.
DR Gene3D; 1.10.630.10; Cytochrome P450; 4.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24292:SF104; CYP9F3-RELATED; 1.
DR PANTHER; PTHR24292; CYTOCHROME P450; 1.
DR Pfam; PF00067; p450; 4.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 4.
DR PROSITE; PS00086; CYTOCHROME_P450; 3.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408}.
SQ SEQUENCE 2116 AA; 244445 MW; 4AAD4F8C421B1B72 CRC64;
MEISLVTLAL LVGLCVAAYR YCTKHYFYFA DKPIPFLKPS FPFGNAGPIL MKKVTLFEHF
KNLYDAFPNG RIHGMFNMRQ PAYVVRDPDL VKQITVKDFD YFADHMTTGM EQSEENNSNH
LLLGNSLVSL RGQKWRDMRA TLSPAFTGSK MRLMFALIAE CGQTMVTYFR SEEQKARASE
GSGLQLEMKD VMTRFANDVI GTAAFGIKVD SFRDPSNQFI SMARSVTSQE SLVKAIKMIG
FTFAPKLMTR LNIDFLTPEE DRFFRDTIME TMRTREEKGI FRPDMIELLM QAKKGSLKHQ
QKEEPKQETD QAAEGFATVE ESHVGKRAHD RVWSDTELIA QAFIFFFAGF ETISWTLSFA
LYELAVNDEV QARLYEEVRE SEQSLDEGQT LSYEKLQSLQ YLDMVISETL RRWPIATVLN
RECVRDYQYD DGQGVKFIIE KGAQIFIPVV GFHFDPKYYP NPERFDPERF SEENRKKIQT
GTYLPFGAGP RNCIGSRFAL MEAKVVLYYL LLHFHVKPCA KTQIPLKLKK SSTQFQTEQG
ICRYSYFLDK PYPHLKPTFL LGSSGPMMLR QRDMIQHIKI LYNTFPDAKV VGAYDMLTPN
LMLRDPECVK QIGVKDFDYF TDHTPFLPNE QDVAGSDNMF LNSLFMLRGQ KWRDMRATLS
PAFTGSKMRQ MFELMSESCE GMVQHLLKEA RADDTKQVHE MKDIFSRFAN DVIASIAFGI
QVNSFADREN DFYVQGKKLL DFSSFWPTIR FMLFMMMPRV MLKLNIEMMD KEMCKHFSAM
ILDNIRVREE KGIVRNDMIN ILMQVKRGVL NHQRDEKDAG FATVHESAVG KKAITREWTD
KELVAQCFLF FLAGFDSIST AIGFMMYELM RHPEIQERLY EEVVEIDEKL NGKPLTYDAV
QGMRYMDMVV SESLRFWPPA PMVDRYCNRD YTFDDGEGLR FKIEKGRTIM VPVAGLHSDP
KYFPNPERFD PERFSEENRH KINPGAYLPF GVGPRNCIGS RFALMEVKSV VYYLLKNFTF
ERCDKTEEPL RLKRSPVALA TENGIWIRLK PREGYLVLVI GFASLLVVLY VYLKKNNKFF
EQFPIPCLPV EPLFGSQRAV LLRQISVNGF IRQSYASFPG AKMYGMFELV TPMFVIRDPE
LVKRITVKDF DHFINHRSMV SGDSSSSSSV MFTKALFNLS GQRWRNVRTT LSPTFTGSKM
RHMFTMIVEC SQNMVQALET ASERECEMKE LFIRFTNDAI ASCAFGVRIN SFRDEQNVFF
RYGKEISNFN RLPVFVKIMG YQFFPKLMGW LDVDIFDRKH VQFFADLFRS QVQEREQHGI
VRPDMIHLQM QAAKGKLRHL PQEREEVESF ATAKESNEEK LLPEGAHTET LSEQEMVAQC
LIFFLAGFDI VANSMSFLMY ELTMASDIQE RLYEEVREVS DSLEGKSLTY DALLGMRYLD
MVVSEVLRRW PPNPASDRQC NQDYKVTGEG GAPDVVIPKG VTVSIPIVGL HHDPQIYPDP
DRFDPERFNE ENRQKIPLGA YLPFGIGPRN CIASRFALME IKAIVYHLLL NFEFQRSDRT
QVPIQLAKGF VPLKAEKGIH LKLKPLLMIG FVSLLVALYV YLTSNNKFFE RFPIPCLPVE
PFFGSCRRLV LKRTSFNEFV RSNYEAFPDA KMFGMFEILT PMFVIRDPEL IKRITVKDFD
HFINHRPLIS ADSANSEGST VMFTKALFNL RSQRWRDVRT TLSPTFTGRK MRQMFTMIVE
CSENMVQALA NPAGQECEMK DLFIRFTNDV IASVAFGVRI NSFRDKENVF FRYGKDLSNF
SRLHVILKMM GYQVFPKLMG WLQMDIFDRK HVEFFTELFR QSVKERQHHG TVRPDLIHLL
MQSSKGTLRH QPSEEPEEVE SFATAKELND EKILPKHPVM LSEGEMVAQC FLFFLAGFDT
LATAISFLVY EVTIASDIQE RLYEEVKQVS ESLEGKSLTY DALQGMRYMD MVVSETLRKW
NPAPGTDRVC NQDYTVPGDP DIIIPKGASV FIPIAGLHFD PQIYPDPDRF DPERFNAENR
QKIPLGAYLP FGIGPRNFIA SRFALMEIKA VVYHLLLNFE FQRSERTTVP IEVAKGFTPL
KPEKGIYLQL IPRKTN
//
