ID A0A182Y1V9_ANOST Unreviewed; 1707 AA.
AC A0A182Y1V9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 03-MAY-2023, entry version 29.
DE RecName: Full=Ricin B lectin domain-containing protein {ECO:0000259|SMART:SM00458};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI02445-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI02445-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI02445-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680}.
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DR STRING; 30069.A0A182Y1V9; -.
DR EnsemblMetazoa; ASTEI02445-RA; ASTEI02445-PA; ASTEI02445.
DR VEuPathDB; VectorBase:ASTE003841; -.
DR VEuPathDB; VectorBase:ASTEI02445; -.
DR VEuPathDB; VectorBase:ASTEI20_031474; -.
DR VEuPathDB; VectorBase:ASTEI20_034314; -.
DR VEuPathDB; VectorBase:ASTEI20_043719; -.
DR OMA; ERHAINE; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR CDD; cd02510; pp-GalNAc-T; 3.
DR CDD; cd00161; RICIN; 3.
DR Gene3D; 2.80.10.50; -; 3.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF131; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED; 1.
DR Pfam; PF00535; Glycos_transf_2; 3.
DR Pfam; PF00652; Ricin_B_lectin; 3.
DR SMART; SM00458; RICIN; 3.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 3.
DR PROSITE; PS50231; RICIN_B_LECTIN; 3.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 461..573
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT DOMAIN 992..1113
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT DOMAIN 1577..1695
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
SQ SEQUENCE 1707 AA; 196076 MW; EB9742DF490C9A19 CRC64;
MYGKYFSTKR DLVWTLVVFC CCLAFYLYHN QLSDRLATLE EFKRIHQEEQ QRTAVRETSS
LEPDYEVVKY ATHYTPVPDD GWIETLPGDM GKPVILPDNI TDAVRQLVQQ GYETQGLNQY
VSDLIPVRRR LPDLRDPWCT SEQRLLTALP QASIVIVFYN EAWSVLVRTV HSILDRTPKE
LIREIILVDD YSNLAHLRTQ LDEYFSSYPL VRVLRVPKRL GLIRARLYGA RNASSDFLTF
LDAHCECMNG WLEGQLDQVV RDPHTIALPT IDWIDENNLK LVSDKAPVFY GAMGWGLDFE
WRGRWDRVHK PANELEPFST PVMAGGLFTI HRKFFAWLGW YDEGMDVYGG ENIELSLKAW
MCGGRMLTVP CARVAHIQKA GHPYLKDVKT DVVRTNSVRV AEVWLDEYAQ VLYGMFGGPQ
FRGDYGDVSS RKQLRKDLHC KDFHWYLENV FPELTEALGK RPGQGTFLND ALAGSPGHCL
TYVKPNNTVS MTPCEQGNVW QQWVFSLYGE IGTDNNCLDY DGNMLLVFHC HKAHGNQEWT
YNRRRNLLVL VAVTVTLALM VVYLVYDVNL TLTPKRNFLA QASSDDDDSE LIRTSSAAVV
NHGFAFVYTS IGLDPRLPTP PGDMGQPVMV NLTSEQIDAL TQEGIQTQGF NQYFFRPDVR
ETQIRDPWCA EPGRFLDNLP KTSIVIVFFN EAWSVVLRTV HSVLDRSPPY LVQEIVLVDD
CSTLANLKTQ LEEYFHRYPK VRVIRAPARL GLIRARIFGA KHTTSDVITF LDAHVECTVG
WLEALLDVVA RNSTTIAIPT IDWIDEKSMA LVANKSISYI GAYDWDLNFG WWHRSSMKKK
YKNMLEPFDT PAMAGGLFSI NRAFFERLGW YDEGFDIYGI ENIELSMKSW MCGGKMVTVP
CSRVAHIQKV GHPYLHNEKK DVVRANSIRL AEVWMDEYKQ IIFDIHGIPH YLEEEFGPIA
DRKAVRKQAD CKDFRYYIKH GFPEMKNPYI TGAFRGEIHS DLLGNGTCLE YRPDDNFLGM
APCDGKQRTQ YWAHNYYQEI NSYRHCLDFT GTSLALFGCH RARGNQAWRV QTDAKQLQSI
KHDRCLAVNT LTNVTLTMQE CDPQNVAQKW TVTFIENFVL VVSVFILLAY LFLTLFYDGG
RGRFDNVLKR IALVQQRNMS NRVYLQEEIL STTSPSTPST TLFKYVYTTL GLDARYPVPP
GDLGNSVEVD HNDTDVSKLV ADGLIDQGLN QFSSDLMSLR RRLPEYRDPW CREPGRYRSD
LPPTSIVIVF YNEAWSVLVR TVHSILDRSP ARLVHEIVLV DDFSNLPHLK TQLEEYFASY
PKIRIVRAPE RLGLIRARML GGKSTKTDVI TFLDAHVEVT IGWLEALIQP VAENWTTITL
PTIDWIDENT MKYRDDKAPT FVGAYDWDLN FGWWSRWSLK KQYENKMVPF DTPAMAGGLF
TIARKFFDRI GWYDEGFDIY GIENIELSVK SWMCGGKLVT VPCSRVGHIQ KTSHPYLAKQ
PKDVVRANSI RLAEVWMDEY KHIIFDIYGI PKYAEEEFGS VATRKAIRQS ANCQSFRYYL
ANVFPEMHNP LVAGAFRGEV HNAALGNGSC LTYRHRDNFI GMAPCDHLEK DQFWTHNYYQ
ELNSYRNCID AVSNVVEVYM CHRLRGNQAW NFLVESRQIE SAEHKLCLAL NLKTNTTLVL
EKCDTTKLNQ QWDVSFIDLD PPQDGTL
//
