ID A0A182Y5L4_ANOST Unreviewed; 1140 AA.
AC A0A182Y5L4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=VWFA domain-containing protein {ECO:0000313|EnsemblMetazoa:ASTEI03750-PA};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI03750-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI03750-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI03750-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A182Y5L4; -.
DR STRING; 30069.A0A182Y5L4; -.
DR EnsemblMetazoa; ASTEI03750-RA; ASTEI03750-PA; ASTEI03750.
DR VEuPathDB; VectorBase:ASTE010785; -.
DR VEuPathDB; VectorBase:ASTEI03750; -.
DR VEuPathDB; VectorBase:ASTEI20_040339; -.
DR OMA; PLFANNI; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF37; VOLTAGE-DEPENDENT CALCIUM CHANNEL UNC-36; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
SQ SEQUENCE 1140 AA; 128197 MW; 18885853453DDF4A CRC64;
MDSAEQAALS ESDPESATSK SHPSGFYDAR RINEYQSDGR LAEGSRQMLL RHMRRFEGYP
VNISLSSVLL PAGVSLDDPE TQSAIKWSSH LDPLFANNIE RDSALSWQYF GSSTGFLRRF
PGTAWPPETS YGSKEINDFR SEDWFIQAAS SPKDVIILLD SSGSMSGKEY QLAVATASAI
LDTLGDDDFF NLISFSDQAR VIVPCFQDKM VRATPDNVKE VKTAINAVEC ENTANFSAAL
ETAFELLRKY NQSSQGSQCN QAIMLITDGP SDTFMEVIKH YNHPHMPVRI FTYLIGTDKS
GGKNLYKMAC ENKGYFVQVN SAEEARKKVV EYALVMARPM VLYQADHPVH WSPVFMGGRS
GILGRESENR RKLVTTVSTP VFDRRNHSTR AANLLGVVGT DVPIEEIQKM IPQHKLGVNG
YAFIVDNNGR VLCHPDLRPL SDNDQYSATL KHKYNSVDLT EVELPEVDNP SNTINERHDQ
RYANTLQELR NEMVLQKEGE NELTVLTHLD TMKRVSLRFQ KYFYGPIDGT PFSLGIALPD
SYGVHELNAQ QEIRHSHINV TEHFKGNNWK VHPDWVYCEY NSLKDADGNG EGTEETTYRD
KDESFDTPEE QVLHFLARVG RPGWKWMSVR PRSPQPHHGH GGIAVGHYAQ HHFNMQGSRK
AEPYYCDRTL VQSLVRDAIV TDGLDRASSQ SRKEDRSRLG FSMFSVKTTF VATRSGLLRW
IDHLPHSEDS SEPHFSETNA RSMDMSWYKR AVDLYATEPE GFVFSVPFNS GYSGKNSSTL
VTASHAIFID HRGHKAPAAV VGLQFMHESL FKHFINITSK CTASTTCKKN CASDELDCYL
LDDNGFVILS ERSEHTGKFF GQIDGTIMDS LVQDRIYRRV PLMDYQGICS DRDNPYTGAS
EPLKPVRPMS WLLKYFVSFA TYWLSVLPTP IGAWQNSNYN YDGTDDLEEE DTYDYEQPDY
DLPPEHSDVT TPDYDQRSTP TPQRSHTQAG PRVAPDPAHA RPCDLKTDLY VLQPERLNSS
GQNNPLKGKL TNCHSSGCER PFSVQKIPNS NLILLVVDVL CPCGSKQLDI EPQEVVGGAG
ACGVRRMAKE KMLRKRPGKC ISYHPEEIEI KQCGTATSLF RASLYTTIAT FIVIWVLASA
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