ID A0A182Y7A9_ANOST Unreviewed; 1132 AA.
AC A0A182Y7A9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000256|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000256|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000256|HAMAP-Rule:MF_03000};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI04345-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI04345-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI04345-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000256|HAMAP-
CC Rule:MF_03000}.
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DR AlphaFoldDB; A0A182Y7A9; -.
DR STRING; 30069.A0A182Y7A9; -.
DR EnsemblMetazoa; ASTEI04345-RA; ASTEI04345-PA; ASTEI04345.
DR VEuPathDB; VectorBase:ASTE010143; -.
DR VEuPathDB; VectorBase:ASTEI04345; -.
DR VEuPathDB; VectorBase:ASTEI20_035190; -.
DR OMA; HQAFQFC; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.860; -; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A; 1.
DR PANTHER; PTHR14005; EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_03000};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000};
KW Initiation factor {ECO:0000256|HAMAP-Rule:MF_03000};
KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03000};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_03000}.
FT COILED 558..701
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03000"
SQ SEQUENCE 1132 AA; 132484 MW; 2E22847DB14B2CB7 CRC64;
MSRYVQRPEN ALKRANEFID VGKKARALDT LQEVFRAKKW NYNWSESVIE PVMFKYLDLC
VELKKSHIAK EGLFQYRNMF QLVNVGSLEN VIRGYLKMAE ERTEQAQQQS SQAILDIDDL
DNLASPESIL MSAVCGEDAQ DRSDRTILLP WVKFLWESYC QCLELLKVNS HCETLYHDIA
RMAFQFCLKY NRKMEFRKLC EKLRKHLEDI CKVSSQTANV SISKPETQQL NLETRLHQLD
SAIQMELWLE AYKAIEDIHG LMALSKKTPL PKTMALYYTK LAMVFWKAGN QLFHASALLK
LFQLSRDMKK NVTAEEIQRM TTHVLIATLA IPLPSAHPEF DRFIETDKSP MEKAQRLAFL
LGLQQSPSRA LLLKELIRLN VLQLAAPQFR HLYQLLEVEF DPLNLCEQVQ KIVDDIEADP
NSVYGQYVQA LKDVTLVRLV RQISQVYQTI EFPRLLELAK FADYHHLERI LVDCVRHNDM
QITIDHRNGC VHFGTDLSES QREDHPDGPT LQSMPSEQIR SQLVNMSVVL HRAIATINPD
RKKAERERLR GQMVHQYKEN ADKEHQRILQ RQKKIEDRKE YIERMNQERE EEELRQQEEQ
ARMLKLAEQR RLEAENEERE RKRHENELQM MKERNMKEKI EQIKQTATGQ KLLKKLDEEE
IRKLNTEEIA AREAEERLKE RKAHENNLKS QEKKIDYFER AKRLEEIPLI EKYLQDRSVQ
DKEFWEKQEA SRIEAAIAER KNAEACQERL KRMLPDRDVY WQQLKNERGN QFAEKLKQFN
QALEEERKRR LADRVVKRRE ERRMKWLKEK EEERRRIEEE IRKQKEEADR IERERRAEER
RIADEKNRQL AEKQLAIAEE VERRRKEELE QKRTEETEAR RDWRTGGGGA GGGGAGGASA
AASEPKPEDS WRRGPAAASA NASADEPKKN VWQGSGRYGP GPRDRAGAGE TGAKDKWRSG
PEDHEKERDG GGMRRGGDMR RGQDDRGPIR RGGDDRGDRD DRGPMRRGVG GAPPSSGAPR
RGDDRPGDRG FNRDRRDDRR DDRGPRGGDR DRDNTWRRGP AESNDENRRG PGQQRDEGRQ
DTWRNTRQEP APKPKEERPQ REPRPQENGT KLNDQLLRHA TTPAQTTTDG RM
//