ID A0A182Y997_ANOST Unreviewed; 899 AA.
AC A0A182Y997;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI05033-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI05033-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI05033-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A182Y997; -.
DR STRING; 30069.A0A182Y997; -.
DR EnsemblMetazoa; ASTEI05033-RA; ASTEI05033-PA; ASTEI05033.
DR VEuPathDB; VectorBase:ASTE002192; -.
DR VEuPathDB; VectorBase:ASTEI05033; -.
DR VEuPathDB; VectorBase:ASTEI20_038284; -.
DR OMA; GPCPKKC; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00064; FU; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 899 AA; 99917 MW; 32E6832CD27DF887 CRC64;
MSVPANREYH YKNLRDRYTN CTYVDGNLEI TWISNITDLN FLQHIREVTG YVLISHIDLP
HVILPGLQII RGRTTFKLNK WEEAYGLFVS FSHMNTLELP ALRDILSGSV GFFNNYNLCH
MKTISWDEIV SDPQVKMQYT FNFSSPEREC PPCHPSCESG CWGEGAHNCQ RFSKLNCSPQ
CSQGRCFGPK PRDCCHLFCA GGCSGPTQQD CLACKNFYDD GVCKQECPPM QIYNPTNYLW
EPNPDGKYAY GATCVRKCPE HLLKDNGACV RKCPKGKMPQ NSECVPCKGV CPKTCPGEGI
VHSDNIGNYK DCTIIEGSLE ILDQSFDGFQ QVYTNFSFGP RYIKIDPDRL EVFSTVKEIT
GFINIQAHHE NFTTLNYFRN LEVVGGRQLK ENLFASVYIV KTSLKSLELK SLKRVNSGSI
VILENSDLCF VEDINWSEIK KSTDHEVMVQ KNRNATACHA EGMQCSEQCS KAGCWGKGPE
QCLECKNVKY KGKCLDSCKS LPRLYQVDSK TCGNCHAECE DFCNGPNADN CGSCVNVKDG
RFCVAECPIM KHAMNGTCIN CHKTCVGCRG PRDTIAKDGC ISCEKAIIGS DATIERCLMK
DEPCPDGYYS DYVLQEEGPL KQLSGKAPKT RPSIMLPGPS AVDPSDEVPK SLRYCKDPLK
PDDETDGNGK EVGVGGIRLN LPLDEDDYLM PTCQSQNQST PGYMDLIGVP ASVDNPEYLM
GSTQAIAGVA HGSMGPHTPP PNSPHGMTMQ TASQHSQIQP QPIQQPLQVL QHQYQQQLQH
QQQQQQQQQQ QQQLQHHHQK QLSQSSHHSS ASNGPSNPSV SHTPSLSNAS SNVGPKQSDS
IMQLQTNGAG LHQQQSSPPT QTIGIPLSPT ETEATSSEHE YYNDLQRELI PLHRNETTV
//
