ID A0A182Y9T7_ANOST Unreviewed; 468 AA.
AC A0A182Y9T7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=glutathione transferase {ECO:0000256|ARBA:ARBA00012452};
DE EC=2.5.1.18 {ECO:0000256|ARBA:ARBA00012452};
DE AltName: Full=GST class-theta {ECO:0000256|ARBA:ARBA00041523};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI05223-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI05223-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI05223-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00000710};
CC -!- SIMILARITY: Belongs to the GST superfamily. Theta family.
CC {ECO:0000256|ARBA:ARBA00009899}.
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DR AlphaFoldDB; A0A182Y9T7; -.
DR STRING; 30069.A0A182Y9T7; -.
DR EnsemblMetazoa; ASTEI05223-RA; ASTEI05223-PA; ASTEI05223.
DR VEuPathDB; VectorBase:ASTE001492; -.
DR VEuPathDB; VectorBase:ASTE016032; -.
DR VEuPathDB; VectorBase:ASTEI05223; -.
DR VEuPathDB; VectorBase:ASTEI20_044946; -.
DR VEuPathDB; VectorBase:ASTEI20_045507; -.
DR OMA; TIAWMER; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR CDD; cd03177; GST_C_Delta_Epsilon; 2.
DR CDD; cd03045; GST_N_Delta_Epsilon; 2.
DR Gene3D; 1.20.1050.10; -; 2.
DR Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR43969:SF4; FI01423P-RELATED; 1.
DR PANTHER; PTHR43969; GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF13409; GST_N_2; 1.
DR Pfam; PF13417; GST_N_3; 1.
DR SFLD; SFLDG01153; Main.4:_Theta-like; 1.
DR SFLD; SFLDG00358; Main_(cytGST); 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 2.
DR SUPFAM; SSF52833; Thioredoxin-like; 3.
DR PROSITE; PS50405; GST_CTER; 2.
DR PROSITE; PS50404; GST_NTER; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000076408}.
SQ SEQUENCE 468 AA; 52780 MW; A5930B9C92E4677A CRC64;
MPKPVLYTVG LSPPCRAVEL TAKALGLDLE RRTVDLLAGD NLKPEFLKLN PKHTIPVLDD
DGTIIGESHA IMIYLVRKYG KTDALYPSDI VQQARVHEAL HFESGVLFAR LRFITELVFF
ARKPEIPDDR IEYVRKAYRL LEDSLCDEFV AGRGMTIADF SCISTVASTV GFIPLDKSEF
PRTIAWMERM KKQLPFYEEA NGAGATALGQ FLVLYTLHLS PPCRAVELTA KALGLELEQK
NINLLAGDHL QPEFLKVSPP VRGVLLTIAA LGVRDRIKFE YINLFAAGHL SADFIKINPL
HTIPVLRHGD LTLIDSHAIL MYLCDTFASE DGGAAFAIRD TLTRAKVFNM LCFNNGHLFQ
RDAELMRKIF SGEITDPSGH LKPIEETIDA LEHFLKQSRY TALDRLSVAD FAIVSTLSTL
DLLVPVKADR WPRVYEWFVE MQSLPYYNEH NRVGLERLRE KLSSRIKI
//
