ID   A0A182YAE0_ANOST        Unreviewed;      1123 AA.
AC   A0A182YAE0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   13-SEP-2023, entry version 28.
DE   RecName: Full=K+/cl-cotransporter kcc1 {ECO:0008006|Google:ProtNLM};
OS   Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI05426-PA, ECO:0000313|Proteomes:UP000076408};
RN   [1] {ECO:0000313|Proteomes:UP000076408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX   PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA   Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA   Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA   Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA   George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA   Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA   Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA   Sharakhov I.V., Tu Z.;
RT   "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT   stephensi.";
RL   Genome Biol. 15:459-459(2014).
RN   [2] {ECO:0000313|EnsemblMetazoa:ASTEI05426-PA}
RP   IDENTIFICATION.
RC   STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI05426-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   AlphaFoldDB; A0A182YAE0; -.
DR   STRING; 30069.A0A182YAE0; -.
DR   EnsemblMetazoa; ASTEI05426-RA; ASTEI05426-PA; ASTEI05426.
DR   VEuPathDB; VectorBase:ASTE003432; -.
DR   VEuPathDB; VectorBase:ASTEI05426; -.
DR   VEuPathDB; VectorBase:ASTEI20_033076; -.
DR   OMA; DTISFEM; -.
DR   Proteomes; UP000076408; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR002443; SLC12A1/SLC12A2.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 1.
DR   PRINTS; PR01207; NAKCLTRNSPRT.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          189..686
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          695..1123
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   1123 AA;  123779 MW;  EA38B4230554C558 CRC64;
     MTDPKGGGGA NDVEMNALPR NQSVNRFQVN LVNHDDPTAA HGTGNGTAAA EPVTEDDVFP
     EEMVKRRTSR LQSLRSSFRT GGDRDPEQPR QRKPSTRFNV EGGESDSNDD EEDNLIDENR
     YARSFRHFTR EALPRMDNYR NILSFQGNQR PTLDELHDAS ITNKETMRRG TVHEPAEMDG
     AIKFGWIKGV LMRCLLNIWG VMLFLRLSWV VGQAGIVQGV VLIVMTTVVT TITALSMSAI
     STNGVIKGGG TYYMISRSLG PEFGGSIGLI FSLANAVACA MYVVGFCESM IDLLASFGLA
     IVDGAVNDVR IIGCITIVLL LCIVVVGMEW EAKAQIVLLI ILLVAIVDFC VGSVWGPKSD
     LDVARGFVGF NASVMMENMN SAYRVVKGTQ HDFFSVFSIF FPAATGILAG ANISGDLKDP
     SSSIPKGTIL AIVLTSASYI GMAIIAGATV LRDATGNLTD VVNGTWDFSN CEVQSCSYGL
     HNSFQVMELV SVFGPLIYAG CFAATLSSAL ASLVSAPKVF QALCKDKLYP KISWFGKGFG
     KNNEPVRGYI LTFIISVAVI LVGDLNMIAP LISNFFLAAY CLVNFSTFHA SLAKPVGWRP
     TFKYYNMWLS LLGAIFCIAV MFLISWPTAL ITFAAVLSLY LIVSYRKPDV NWGSTTQAQT
     YKNALLSVQQ LNNVEEHVKN YRPQILVLGG HPSARPLLVN FAYLLTKKLS LLVCGHVTKT
     HVSQKYRNHL QRKAGEWFRR HKVKGFYSLI DDNDFETGAR AIMQASGIGK LRPNVLLMGF
     KSDWDRCESG ELEQYFNVVH KALDMYLSVA ILRVGKGFDY SQVLGEDTVK FISEYPRTLV
     ANDSTNDLLG HNKVSSLHGS CDSLSRNVSQ ASSTSDLSKT ISVAPDPIDI NAKLITETGQ
     RSLKRGDPSL LYRGPGGSEL PKEVLDELTQ FTSKKKTGII DVYWLYDDGG LTLLLPYIIS
     TRRNWSSCKL RVFALANRKT ELEFEQRNMA SLLAKFRIDY SDLQLLPDVT KKPNQEMADF
     FKALIKEFTA KDDTSDASTA GASCISKAEL LAVQDKTNRH LNLREYLLQH SSKSDLVVMT
     LPMPRKGVVS APLYMAWLEA LSRDLPPFLF VRGNQTSVLT FYS
//