ID A0A182YCH8_ANOST Unreviewed; 1435 AA.
AC A0A182YCH8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Centaurin-gamma-1A {ECO:0008006|Google:ProtNLM};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI06164-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI06164-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI06164-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR STRING; 30069.A0A182YCH8; -.
DR EnsemblMetazoa; ASTEI06164-RA; ASTEI06164-PA; ASTEI06164.
DR VEuPathDB; VectorBase:ASTE003872; -.
DR VEuPathDB; VectorBase:ASTE003873; -.
DR VEuPathDB; VectorBase:ASTEI06164; -.
DR VEuPathDB; VectorBase:ASTEI20_031093; -.
DR VEuPathDB; VectorBase:ASTEI20_036350; -.
DR OMA; WQLGGSM; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08836; ArfGap_AGAP; 1.
DR CDD; cd04103; Centaurin_gamma; 1.
DR CDD; cd05911; Firefly_Luc_like; 1.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR PANTHER; PTHR45819:SF5; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
SQ SEQUENCE 1435 AA; 155617 MW; 549D459A7FB235FF CRC64;
MAGTDSFVNS QEWTISRSVP DIRLGIVGSL SSGKSALVHR YLTGTYMQEE SPEGGRFKKE
IQIDNQSYLL LIRDEGGPPE IQFAAWVDAV IFVFSLDNES SFNAIYTYYN RIAHHRNTAE
IPFILVGTQD GICERAPRVI DDARARKLAQ DLKRCTYYET CATYGLNVER VFQDACQKIV
QQRLSTGSTI TPTNSRPTTP QGTRLGVASF HPSVPSPTNG FSGGPQLGSN SSPSHQPQQH
PQNHQNSAGG TMTLPHRHHV LSASSHHIPI KISQELISAE SQHHHHHSNV AGANGGGTQK
WGTISHGTSQ QALLALTNEN NNIAKFVPPT HPVSSGPIDT LQPLGLSAMS AKDSSSSGGG
KDGKDGKELP TPTSTPTTSR KSRRRSNLFI PSSSKKEQQQ QEKIKNGELG SGRAIPIKQG
YLYKRSSKSL NKEWKKKYVT LCDDGRLTYH PSLHDYMEDV HGKEVSLQYV TVKVPGQKPR
GTKSIITNSA LTAAAAAAAQ ASSSTNGTNG SNGGATASSN GLTEGIGGLS LAKDRKCTEK
VLLTAFDTLR EPVKSNSQTS GDEGIVISSS NSQGFLGCDS SSNTTGAGGG GSKIDAQTPN
VKKRHRRMKS SGVGKNSEYD DSDGFEFYIV SLDNKQWHFE ASNSEERDEW VSVIEQEIFK
SLQGIESSKS KPLNPSDIAS MQSIRSRVPG NGYCVDCDSP NPEWASLNLG VLMCIECSGV
HRNLGSHISK VRSLGLDEWP PGHLSVMLAI GNSLANSVWE ANTRGRVKPT PASSREEKEA
WIRSKYEGKD FLPHFNPSPP IGQQLCEAVV RSDMKSIIIL LANASNEHIN STASNRDLRT
PLLLACAIGN LAISQLLIWH HANLKHVDSE GRSCLTFAKA ANSLAAAKQA TNSPHHVNVE
TTTALVELLT SLGCTDPAPF SASAAGIGRI VLDSMSRCPE RVIQINADTG RRTTCAEMKL
RIVRVALHLR RLGYKRGDFV SLACANGENV VPVLIGCWVL GLAVNPLAPV FGREDFEHMM
KQTQSSLVFC DPANYAVVAE AARNVIRAKV QLFVMGEATV GGSSVDELLE PIDGENSFRA
EYLGDATKLL AMVLCSSGTT GLPKGVCLSH AHFIDGTVFS TEISDGPIFN FSSLFWATGI
FAVMTSLLHS RPRVLTSKPY QPDLLLDLIE KYRIENLFTP PSYVSALLAH PRHATADLSS
VRQWQLGGSM VPPELILRLQ KLLPNGHLRS IYGSSEIGFI TRNDVTVKPG SVGPLTTNVE
CRVVDEDGQV VGPGVSGELL LRYRYMFLGY LYNEESTKNA LTEDGFFRSG DIGYMEADGS
LYVIDRIKDI IKYNNFQVSP SDLESVIQKI DGVKQVCVIG IPSPDGSTDL PLAVVERKPG
SALQAEDIVR HVDGQVTDFK RLRGGVRFVD GFPMTPSGKI VRRVVKQMIN NEAAS
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