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Entry: A0A182YE25_ANOST
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ID   A0A182YE25_ANOST        Unreviewed;       294 AA.
AC   A0A182YE25;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   05-DEC-2018, entry version 13.
DE   RecName: Full=Superoxide dismutase [Cu-Zn] {ECO:0000256|RuleBase:RU000393};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000393};
OS   Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=30069 {ECO:0000313|VectorBase:ASTEI06711-PA};
RN   [1] {ECO:0000313|Proteomes:UP000076408, ECO:0000313|VectorBase:ASTEI06711-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indian {ECO:0000313|Proteomes:UP000076408,
RC   ECO:0000313|VectorBase:ASTEI06711-PA};
RX   PubMed=25244985; DOI=10.1186/PREACCEPT-1262842421127991;
RA   Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA   Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA   Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA   George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA   Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA   Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA   Sharakhov I.V., Tu Z.;
RT   "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT   stephensi.";
RL   Genome Biol. 15:459-459(2014).
RN   [2] {ECO:0000313|VectorBase:ASTEI06711-PA}
RP   IDENTIFICATION.
RC   STRAIN=Indian {ECO:0000313|VectorBase:ASTEI06711-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000393}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 copper ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.
CC       {ECO:0000256|RuleBase:RU000393}.
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DR   VectorBase; ASTEI06711-RA; ASTEI06711-PA; ASTEI06711.
DR   Proteomes; UP000076408; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   CDD; cd00305; Cu-Zn_Superoxide_Dismutase; 2.
DR   Gene3D; 2.60.40.200; -; 2.
DR   InterPro; IPR036423; SOD-like_Cu/Zn_dom_sf.
DR   InterPro; IPR024134; SOD_Cu/Zn_/chaperone.
DR   InterPro; IPR018152; SOD_Cu/Zn_BS.
DR   InterPro; IPR001424; SOD_Cu_Zn_dom.
DR   PANTHER; PTHR10003; PTHR10003; 2.
DR   Pfam; PF00080; Sod_Cu; 2.
DR   PRINTS; PR00068; CUZNDISMTASE.
DR   SUPFAM; SSF49329; SSF49329; 2.
DR   PROSITE; PS00087; SOD_CU_ZN_1; 2.
DR   PROSITE; PS00332; SOD_CU_ZN_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000076408};
KW   Copper {ECO:0000256|RuleBase:RU000393};
KW   Metal-binding {ECO:0000256|RuleBase:RU000393};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000393};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW   Zinc {ECO:0000256|RuleBase:RU000393}.
FT   DOMAIN       10    148       Sod_Cu. {ECO:0000259|Pfam:PF00080}.
FT   DOMAIN      154    276       Sod_Cu. {ECO:0000259|Pfam:PF00080}.
SQ   SEQUENCE   294 AA;  30522 MW;  67B939E77DAE44FB CRC64;
     MPLKAVCVLN GEVKGTIFFE QSAESDPVKV TGSVTGLKAG DHGFHIHEFG DNTNGCMSTG
     AHFNPHGKTH GAPDADERHA GDMGNIVADA SGEAKVDLVA SQIALSGPMN VVGRSLVVHA
     DPDDLGLGGH ELSKTTGNAG ARLACGVIGL CKGSSVAITG AVEGLRPGKH GFHIHEFGDF
     SRGCLSTGPH YNPDGNDHGA PDDCNSHAGD LGNIMAYSTG LAKVQIAARK ITLAGDRSII
     GRTLSITEFE DDLGRGRHDY SKTTGNSGNC IACAIIGVAR EEYFAERLHL TTDE
//
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