ID A0A182YG08_ANOST Unreviewed; 1169 AA.
AC A0A182YG08;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI07394-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI07394-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI07394-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR AlphaFoldDB; A0A182YG08; -.
DR STRING; 30069.A0A182YG08; -.
DR EnsemblMetazoa; ASTEI07394-RA; ASTEI07394-PA; ASTEI07394.
DR VEuPathDB; VectorBase:ASTE001358; -.
DR VEuPathDB; VectorBase:ASTEI07394; -.
DR VEuPathDB; VectorBase:ASTEI20_031946; -.
DR OMA; GPHPSIC; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF71; ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT DOMAIN 441..529
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1169 AA; 131033 MW; 388E3E7E1EEE3BD0 CRC64;
MKLFRRGSPR CIGLLSAFVT ILLCLYYISM GQPSPAGSGS SAPTGMDGKD ASGSVAVGAA
HQKRSNGQHT GPHANHSWHS WLRSSLNSIG GGGAAGSRQQ RIADRVGDNL RGDSGDADDS
GGTGGTDNDG GAGAGDGGPL PRFGSRWDEC NVLEEASTDI TTVDEYGKFD FQILKKLVQS
GRLEITTGGW VMTDEANAHL YAMVDQLIEG HQWVKANLNI TPKTGWSIDP FGHGSTVPYL
LAASGFKGTI IQRIHYAWKQ WFARHRYGDF LWTPYWKSPS NSAPDHTMLT HNMPFDIYSI
KHSCGPHPFI CLNFDFRKIP GEYTEYSIKA QFITPENIEA KADLLMEQYS RTASLFPHNV
ALIPVGDDFR YNKEKEMEQQ YTNYKKLIDY INEHRQKYNA EISFGTPVDY FTAIRERYDR
FPTLKGDFFV YADIFNEGRP AYWSGYFTTR PYYKILSREL EHNLRSLEIL FTIAFNRARQ
TGSSNAFKIY EKNYEKMILA RRNLGLFQHH DAITGTSKAN VMRDYALRLF ESIQDTVKLQ
EKTIELLVQR KPLDQQHGFL IGELERDNFG KLPRKTPIIV TEGRSTDFIV YNALAQERLE
VVTIRTLTPR VKVLDASGKT IDIQINPVWN ITETSYTSRK IVPSDKEYEV MFVARLAPLS
LTTYTAAYDE DGYQGKMATL YCTECQDEKT KAFEVRSKQP GDIQLENYKM RLLFDEQSGF
LKSVTKKHMG KQIQCAIKFA AYKSAQFHSG AYLFKTDPEQ RNSEKDVLEQ YGDLTILITS
GPLASDVTAI YGPFLAHTVR IYNSNSVLDS AIYIENDIDF EAPPKNRETE LFMRFVTDIE
NGASENPEFY SDLNGFQYQK RVKVSAIGVE GNYFPITSGA FIQDERMRLT LLTTHAQGAA
SLEPGQLEVM LDRRTLYDDY RGMGEGVIDS RLTRHRFWLT LETIDAPAAA AQPNPPEPNS
NNNNNEDPQK PGADPYQLPS IFANALANGL NYPANLFIVE RYDESNQLEL NRAVRLLRVQ
FPCDLHMLNL RTLTESNLPL FPSSSALLVL QRQGYSCRIG GDEMIGYFCG NGSSSSSSSN
NVGGSSSTSN PSKNAVIDGG GGGGGGGGGN EIDHRQPEVR ELQLFRRLRI DTIQATSLTG
LHPGERINAF TDIYLEPMEL KTYNLTFSK
//