ID A0A182YG57_ANOST Unreviewed; 1132 AA.
AC A0A182YG57;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Lateral signaling target protein 2 homolog {ECO:0000256|ARBA:ARBA00019870};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI07443-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI07443-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI07443-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Negative regulator of epidermal growth factor receptor (EGFR)
CC signaling. {ECO:0000256|ARBA:ARBA00003580}.
CC -!- SIMILARITY: Belongs to the lst-2 family.
CC {ECO:0000256|ARBA:ARBA00008755}.
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DR AlphaFoldDB; A0A182YG57; -.
DR EnsemblMetazoa; ASTEI07443-RA; ASTEI07443-PA; ASTEI07443.
DR VEuPathDB; VectorBase:ASTE001401; -.
DR VEuPathDB; VectorBase:ASTEI07443; -.
DR VEuPathDB; VectorBase:ASTEI20_043599; -.
DR OMA; CNRCFLY; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15731; FYVE_LST2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR043269; FYVE_LST2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46465; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR PANTHER; PTHR46465:SF2; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 1132 AA; 123789 MW; 2DE8F55F0DDA0665 CRC64;
MSMHHLYRPW DVLVFWHADD KSLLARFYHA DRALTAIASE LDSFDGRAEP VRCTRLVSRL
RQGQDRVLAI TNQIMDELLG DDRAQRAFRV KFPEEVLQES LAGQLWFGAE CLAAGSSILN
REAESAKMRP LAKAVTKSLE IVRNRLREQC LRNNTPNSPT LRLDFNDAAT EQLYESLKIF
DRLFAEFELV YVSAMVQVKT KQEYEMQELI CVLFSETLQR ALKIGLLDQE QVDSYDPALM
FSIPRLAIIA GLVIFRDGPL NMDQPADNIS EIFRPFRKLL IKMRDLLHTL TKHELYQLEK
LLCTNEEISA SEQLICDEKN GGGAGGDTGA SENVRGDIDA HEPVGESKEH VVIVTTTTIT
TTNASDGKTN VNDGDEGGVH VVSQGFEVTT SSAGGELNGS GSNGINTECC STSRAKNQHN
QRHLRQCSKT VSYGRDTGVV QQEIEPEVEE DNNNHIHKDD DVDEDDEDDE DDNDPELKDG
LVTTDCASGY LIPNTNFGNL LQTNEAPLTD SFIATDDELR LLGADVGSPS TQANIDSILT
GATNPGGEQQ KLVDSDSGHG TASHSTDMSP ELETERTVAE NTVEPKLNAD DAPLSTVVSA
ESNASKSVRN RSRSVGSLHK PPEISESSSD DEEEADVYGA DDVDADDDED EEEEGDEKKS
AADIKFVLGG SQKDYKLYDA KDISGRPSSS QTKQPQYNNH RKPSHHRPRA STSTSTSSAY
RKPQSHQHHH HHHHHHHHHS YSAATEATSS VASTTTTSNS NATNGSARHS RMQHQQHQRS
SSSSCDTSPT QSECSDAQEV ALAIRAAGRN NFQTTENLLH RLFVCIAGVA DQLQTNFAAD
LRKMLRSVFI MNSSPPEPEE PPEANAHEVE SKDNHHNPSD LFEFRASEQD VITADQQNHS
GGSSQSIYSA EEANPEQDSV FASSGDSSPV RRTASVETSN VTVNVSVSVV ASSPVSVGGP
NSGHSNSAGG GRTAQERSVS LSEACIVVEG GKPSTGTRRH SASGSKSDYG RSRSSPSSPS
NSNSNGGSNH HANTTTSSSG RDLHVEQQQQ QQHLSSQRRM PEEPPRWIPD CDAPRCMSCA
SAFTPFRRRH HCRNCGGVFC GVCSNLSKPL PKYGLTKAVR VCRDCYVHEV GV
//
