ID   A0A182YH40_ANOST        Unreviewed;       411 AA.
AC   A0A182YH40;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5 {ECO:0000256|ARBA:ARBA00016279};
OS   Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI07776-PA, ECO:0000313|Proteomes:UP000076408};
RN   [1] {ECO:0000313|Proteomes:UP000076408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX   PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA   Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA   Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA   Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA   George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA   Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA   Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA   Sharakhov I.V., Tu Z.;
RT   "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT   stephensi.";
RL   Genome Biol. 15:459-459(2014).
RN   [2] {ECO:0000313|EnsemblMetazoa:ASTEI07776-PA}
RP   IDENTIFICATION.
RC   STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI07776-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000256|ARBA:ARBA00005339}.
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DR   AlphaFoldDB; A0A182YH40; -.
DR   STRING; 30069.A0A182YH40; -.
DR   EnsemblMetazoa; ASTEI07776-RA; ASTEI07776-PA; ASTEI07776.
DR   VEuPathDB; VectorBase:ASTE001307; -.
DR   VEuPathDB; VectorBase:ASTEI07776; -.
DR   VEuPathDB; VectorBase:ASTEI20_044490; -.
DR   OMA; MNIVKDY; -.
DR   Proteomes; UP000076408; Unassembled WGS sequence.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   CDD; cd00757; ThiF_MoeB_HesA_family; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   PANTHER; PTHR10953:SF9; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000076408}.
FT   DOMAIN          84..308
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
SQ   SEQUENCE   411 AA;  45177 MW;  8C3471D1F2B093B0 CRC64;
     MEHEGKQSES AVKVGRERIE KMSAEVVDSN PYSRLMALQR MGIVKEYEQV RQKSVAVVGK
     RIPFTCGAFG LNCISMNDMV FRFVGVGGVG SVTADMLTRC GIGKLLLFDY DKVELANMNR
     LFFTPDQAGL SKVEAAAKTL NFINPDVSIT THNYNITTVD NFDRFLDAIR TGGIAQDTPV
     DLVLSCVDNF EARMAINTAC NELSLNWFES GVSENAVSGH IQFIRPGETA CFACAPPLVV
     AENIDEKTLK REGVCAASLP TTMGIVAGML VQNTLKYLLH FGTVSDYLGY NAMIDFFPRM
     SLKPNPTCDD RFCLERQKEY LAKPPSVVEA VAEPETEEPL HEDNLYGIEL VEDDDTPVAA
     SESKVQSNIV EGLKLAYDAP VVEENAPQVT TDDDVSLDQL MAQMSGMCKK E
//