ID   A0A182YJE3_ANOST        Unreviewed;       603 AA.
AC   A0A182YJE3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   13-SEP-2023, entry version 31.
DE   RecName: Full=Caspase family p20 domain-containing protein {ECO:0000259|PROSITE:PS50208};
OS   Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI08579-PA, ECO:0000313|Proteomes:UP000076408};
RN   [1] {ECO:0000313|Proteomes:UP000076408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX   PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA   Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA   Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA   Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA   George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA   Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA   Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA   Sharakhov I.V., Tu Z.;
RT   "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT   stephensi.";
RL   Genome Biol. 15:459-459(2014).
RN   [2] {ECO:0000313|EnsemblMetazoa:ASTEI08579-PA}
RP   IDENTIFICATION.
RC   STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI08579-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMEM198 family.
CC       {ECO:0000256|ARBA:ARBA00006244}.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134}.
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DR   AlphaFoldDB; A0A182YJE3; -.
DR   STRING; 30069.A0A182YJE3; -.
DR   EnsemblMetazoa; ASTEI08579-RA; ASTEI08579-PA; ASTEI08579.
DR   VEuPathDB; VectorBase:ASTE016481; -.
DR   VEuPathDB; VectorBase:ASTE016482; -.
DR   VEuPathDB; VectorBase:ASTEI08579; -.
DR   VEuPathDB; VectorBase:ASTEI20_033169; -.
DR   VEuPathDB; VectorBase:ASTEI20_036414; -.
DR   OMA; QHAVQRI; -.
DR   Proteomes; UP000076408; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR025256; DUF4203.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   InterPro; IPR040236; TMEM198.
DR   PANTHER; PTHR31247:SF5; DUF4203 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR31247; TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER; 1.
DR   Pfam; PF13886; DUF4203; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          200..333
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
SQ   SEQUENCE   603 AA;  66816 MW;  3325F01C5C7E5881 CRC64;
     MNYVKQSSDW EDELLEALTI TEQNLLLLRA GFDDEELRLK YFPRTSEISF LVHPMLKGLY
     NFCERLDDAN ASKLIVQLQE TTGVSSLQNQ NMETVLLHLL CNGKIQLGSK QSGQESNLLV
     LTAACKAIEL YDESDFLKSI VSHFNRHTSK RDQEQSDAST KNIPETTDVA SKHNPTGTIV
     ATVETNHSPL IESYTFSAER AGIVLLINQF SFYRETNPEL VELVPARPLK DRKGTEVDKN
     ALESLFTEFG YDLILEENIT HHQILQAVQH AVQRIKPIHC SLIVCLLSHG QEGKVFGSNS
     IPVEVKAIQQ LMANERLTGK PKLLIVQACQ GADLQSAVPI PNHEHDGPDG ALAVVAGLFG
     AVLGSTHPIS STLIGASAGA LVAGATIAAC IATLPHYIFG ENELFVSVVG GAIICAIVTL
     FCPKFMSIIA SSIIGSAMIL CSIDFFMHGL KTLEWIFNMT PDPTPPPCWG GVILCCWPIS
     SVLGVLVQSF VTAWKIDHRR QLHHRRRRHY KGRSGSRSRE TREEARQRKY RYLYQVRTAR
     GDIISQNFVS ALQKHVTTDS GPPSEVSTKL GSNDRNTARS DRTHLTNLPD SDFDKMDSSC
     EKR
//