ID A0A182YKY1_ANOST Unreviewed; 2709 AA.
AC A0A182YKY1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Xanthine dehydrogenase {ECO:0008006|Google:ProtNLM};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI09117-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI09117-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI09117-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302;
CC Evidence={ECO:0000256|ARBA:ARBA00001924};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the xanthine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00006849}.
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DR STRING; 30069.A0A182YKY1; -.
DR EnsemblMetazoa; ASTEI09117-RA; ASTEI09117-PA; ASTEI09117.
DR VEuPathDB; VectorBase:ASTE011456; -.
DR VEuPathDB; VectorBase:ASTEI09117; -.
DR VEuPathDB; VectorBase:ASTEI20_035495; -.
DR VEuPathDB; VectorBase:ASTEI20_038906; -.
DR VEuPathDB; VectorBase:ASTEI20_045971; -.
DR OMA; LETNMEW; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd00207; fer2; 2.
DR Gene3D; 3.10.20.30; -; 3.
DR Gene3D; 3.30.465.10; -; 2.
DR Gene3D; 1.10.150.120; [2Fe-2S]-binding domain; 2.
DR Gene3D; 3.90.1170.50; Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead; 2.
DR Gene3D; 3.30.365.10; Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain; 9.
DR Gene3D; 3.30.390.50; CO dehydrogenase flavoprotein, C-terminal domain; 2.
DR InterPro; IPR002888; 2Fe-2S-bd.
DR InterPro; IPR036884; 2Fe-2S-bd_dom_sf.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR006058; 2Fe2S_fd_BS.
DR InterPro; IPR000674; Ald_Oxase/Xan_DH_a/b.
DR InterPro; IPR036856; Ald_Oxase/Xan_DH_a/b_sf.
DR InterPro; IPR016208; Ald_Oxase/xanthine_DH-like.
DR InterPro; IPR008274; AldOxase/xan_DH_MoCoBD1.
DR InterPro; IPR046867; AldOxase/xan_DH_MoCoBD2.
DR InterPro; IPR037165; AldOxase/xan_DH_Mopterin-bd_sf.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR005107; CO_DH_flav_C.
DR InterPro; IPR036683; CO_DH_flav_C_dom_sf.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR002346; Mopterin_DH_FAD-bd.
DR PANTHER; PTHR11908:SF132; ALDEHYDE OXIDASE 1-RELATED; 1.
DR PANTHER; PTHR11908; XANTHINE DEHYDROGENASE; 1.
DR Pfam; PF01315; Ald_Xan_dh_C; 2.
DR Pfam; PF03450; CO_deh_flav_C; 2.
DR Pfam; PF00941; FAD_binding_5; 2.
DR Pfam; PF00111; Fer2; 2.
DR Pfam; PF01799; Fer2_2; 2.
DR Pfam; PF02738; MoCoBD_1; 2.
DR Pfam; PF20256; MoCoBD_2; 2.
DR SMART; SM01008; Ald_Xan_dh_C; 2.
DR SMART; SM01092; CO_deh_flav_C; 2.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 3.
DR SUPFAM; SSF55447; CO dehydrogenase flavoprotein C-terminal domain-like; 2.
DR SUPFAM; SSF47741; CO dehydrogenase ISP C-domain like; 2.
DR SUPFAM; SSF54665; CO dehydrogenase molybdoprotein N-domain-like; 2.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 2.
DR SUPFAM; SSF56003; Molybdenum cofactor-binding domain; 2.
DR PROSITE; PS00197; 2FE2S_FER_1; 3.
DR PROSITE; PS51085; 2FE2S_FER_2; 3.
DR PROSITE; PS51387; FAD_PCMH; 2.
PE 3: Inferred from homology;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Iron {ECO:0000256|ARBA:ARBA00022714};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022714};
KW Molybdenum {ECO:0000256|ARBA:ARBA00022505};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408}.
SQ SEQUENCE 2709 AA; 297377 MW; BB7EFFF419E46004 CRC64;
MLSTLGSYIW GSTEADSPLA EVTFTINGKP YTVDPRTIPV DTSLNTFIRN HAHLTGTKFM
CLEGGCGACI VNVSGVHPVT KEKKSWAVNS CLYPIYACHG LDVKTVEGIG NRKDGYHPIQ
QRLAHLNGTQ CGYCSPGMVM NMYSLMEANR GAISMEDVEN AFGGNICRCT GYRPILDAFK
SLTVDADEKL LDACQDIEDL TKRTCPKTGS PCAGKCVSAK DRIDPKRPVR MVFEDAREWH
RVTQMSDIFA IFEQIGNKPY MLVAGNTAHG VYRRSPSLQV FIDINAVEEL HTHSSDANEL
VVGANVSLTE FMHILDETAN KSPNFSHFKH LEKHIDLIAN VPVRSAGTIA GNLNIKNQHH
EFPSDMYLIL ETAGAKLTVV ETGGKTSVIT PADFVRLDMQ KKVLKSITLP ALDISRYQFR
SFKVMPRSQN AHAYVNGAFL VKFAEGGVTV ESAKICFGGI NPDFTHATAT EAFLVGKNMF
DAETIQATMN QLSNEIRPDW VLPDASGEYR KNLAMALYYK YLLNVAPEGT VLVKPSFRSG
GTVLERPLSS GQQTFDTYER NWPLTKNIPK IEALAQTSGE AKFTNDLPPQ PGELYAAFVI
ATKPHTRIGT IDATDALKYP GVVAFYAAKD IPGTNNFMPP SLGNQEPEEV FCSGEVLYHG
QPVGVILAET LNQANHAAGL VNILYERVSQ QQPVYPTLKS LVDNQAKARI FDEPSTTTRR
GSNYRVKVSA ARKVTGRFEM AGQYHYTMET QSCVCVPIED GMDVHCSTQW VDLCQVAIAS
MLKVPENSLN FSVRRLGGGY GSKISRAAQV ACACALAAHL QNRPVRFVLT IESNMSSIGK
RYGCISDYEV DVETSGRIVK LTNNYMQDYG ASLNESVGEA TTEFFNNCYD TKTWKVVGKA
AKTDAPSNTW CRAPGTTEGI AMIENIMEHV AWELGLDPLE LRLMNMPEGS KMRELLPQFR
KDVEYNQRKA DIDTFNVNNR WRKRGIAVSL MRYPLGYFGA LHALVAIHAG DGTVSVTHGG
IEMGQGMNTK AAQVAAYVLG LPLEKISIKP MTSLTSPNAI VTGGSMTSEA VCYAVKKACE
ILLERIKPVR DAHKDAPWET ITQLCYAGSV DLCATYQYRA SELKPYIIWG LSCAEVEVDV
LTGNVQLRRV DILEDTGESL SPGIDVGQIE GAFVMGVGYW LTEALVYAAE DGALLTNRTW
TYKPPGAKDI PVDFRVRFLQ KSSNPAGVLR SKATGEPALN MSIVVLFALR NALRSARKDA
GLADDWIPMG TASTPDQVHL LAGNSIEHPL SEVTFTINGK TYTASAESVP VDTSLNAFIR
NHAHLTGTKF MCLEGGCGTC VVNASGLHPV TKENKTWSVN SCLFPVFACH GLDIKTVEAL
GNRTDGYHPI QERLAHMNGS QCGYCSPGMV MTMYSLMESK QGSVTMEEVE NELGGNICRC
TGYRPILDAF KSLASVTDKE LPDIEELQIC PKTNTACSAK CPQAANLIVP GCPVQVVASD
DKEWHKVYTL AEIFAIFGKI DKRPYMLVGG NTAHGVYRRS ESLQVFIDIN SVEELRNYFL
RTGELVVGAN VTITEFIEIL TKTANNRPNF SYCREIARHL GRIANPAVRN AGTVAGNLSI
KNKYPQFPSD IYILLEAVGA KVIIADSLTK VLEKSAQDYA QTDMTKRLIK FISLPLINTF
TTTFKSYRVA PRAQNAHAYV NAAFLVQFAK DKSTIKLATL CFGGINPKFT HASRTEKLLI
GKKLFDAATI QQAIGSLASE IQPDWVLPDA SVEYRKNLAI ALFYKFLLSV ATDNNVPLNP
RFKSGSTMLE RPLSSGQQNY DTNKKNWPVT KYVPKLEGLR QASGEAKYAN DFPPFPGELY
AAFVVATQPN ATIGKIDPTD ALKLPGVAAF FSAKDIPGTN NFMSSAMNFY FPDVEEIFCS
GRVLFHGQPV GVIVADRFDQ AIRAAKQVKI IYERVSDEPV CPTLKAVLMN QAKERIVDRP
ASSREGPQID LAVSKQIVGT LELAGQYHFT MEPQTCVCVP IEDGMDIYAA TQWIDLSHVA
VAAALKVPQN SLNFTVRRVG GGFGCKLTRV SQIVCACALA AHLTKRPVRF IMNIEANMGS
IGKRYGCVSN YQVDVDAKGK ILKLTNNFMQ DYGSNLNENV IDDAKVVFGL SYNSSAWKVE
GKAVLTDAPS STWMRAPGTT EAIAMIETIM EHIAWVTGVD PMQVRLSNMP AESKLQKLMP
QFRQDVEFDK RKKLIDDFNA KNRWRKRGIA MIPMQYPLVH VGALHAQVSI HANDGTVSIS
HGGIEVGQGI NTKAAQVAAF TLGIPLETIS IKPSNSMTSP NAVMTGASMT SEVVCLAIKR
ACEILNTRLQ PVRSELKNAS WEKITQTCYI RDIDLSVLYQ YKKSDLKPYS IWGLSCAEME
VDILTGNVQL TRVDILEDTG ESISPGIDVG QIEGAFITGL GYWLTESLVF DMTNGALLTN
RTWNYKPPGA KDIPVDFRIR LIQTGDNQGG VLRSKATGEP AMTMTVVLLF ALRYALRSAQ
KDAGRPDDWI PLGSASTPEQ IFLKASNNFE QFKLHVPVNT SLNAFIRNHT HLSGTKFMCL
EGGCGACAVN VSGLHPVTKE NKTWSVYSCL FPVFACHGLD IKTVEALGNR TDDIPVDFRI
RLVQTGENQV GSKATGEPAM SMAVVVVFAL RYAVRSAQKD AERPDDWISL GSAMTPEHIF
LSAKYFTLF
//
