ID A0A182YM85_ANOST Unreviewed; 718 AA.
AC A0A182YM85;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=MaoC-like domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI09571-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI09571-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI09571-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR AlphaFoldDB; A0A182YM85; -.
DR STRING; 30069.A0A182YM85; -.
DR EnsemblMetazoa; ASTEI09571-RA; ASTEI09571-PA; ASTEI09571.
DR VEuPathDB; VectorBase:ASTE002274; -.
DR VEuPathDB; VectorBase:ASTEI09571; -.
DR VEuPathDB; VectorBase:ASTEI20_040190; -.
DR OMA; WATKVHT; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 1.
DR Gene3D; 1.10.287.4290; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408}.
FT DOMAIN 470..586
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT DOMAIN 616..713
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 718 AA; 77176 MW; 462C38F0D5E4B0EB CRC64;
MVAPKEQLRY DGRVVVVTGA GAGLGREYAL LFASRGAKVV VNDLGGNFHG QGKSNAADKV
VEEIRAAGGV AVADYNSVVE GDKIIQTALE SFGRIDVLVN NAGILRDRSV ARISDEDWNL
IHDVHLKGSF LTTRAAWPVM KKQNYGRIIM TSSNSGVYGN FGQANYSAAK LGLVGLANTV
AIEGAKNNIH CNVIVPTAAS RMTEGILPEI LFNELKPKLI APVVAYLCHE SCDDTGAIIE
SAAGWATKVH FVRGKGCVLR TAIDEDVSPE YVQQVWNRVT DMSEARHLNA IGEASLSLVG
VLEKLRDGQN NENSVTETFR YGFKDAILYA LGVGASVSDP TDLKFLYENN PDFGVLPTFF
ILPGLLAVMG SSLTASAIKH TTFDLTNILH GEQYIELFEA PATEGILTTT STVLDVVDKK
SGALVITQSD SYDEQGTLIA RNQSSTFVVG AGNFNGKTKA GPEVKPLVPN PKRSPDASVE
VSTHKDQAAV YRLSGDLNPM HIDPSFSAIA GYKVPILHGL CTMGVSVKAV LKQFGGDDPA
LFRAAKVRFS KPVLPGQTLR VDMWKEPNNR VCFRTVVVET NTEVLSGAYV DFKQIVIKPN
MTSAVTLQSD AVFAGIKDRV AENEAKAKAI NAVFLYKITS GGKVAKEWVL DLKNAKVYEG
PAQGKADTTM TIADADMLEL ALGKLQPQTA FMKGKLKITG NIMLAQKLAP LLKTEAKL
//
