ID   A0A182YQ59_ANOST        Unreviewed;      1295 AA.
AC   A0A182YQ59;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   03-MAY-2023, entry version 28.
DE   RecName: Full=Cytoplasmic FMR1-interacting protein {ECO:0000256|PIRNR:PIRNR008153};
OS   Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI10595-PA, ECO:0000313|Proteomes:UP000076408};
RN   [1] {ECO:0000313|Proteomes:UP000076408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX   PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA   Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA   Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA   Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA   George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA   Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA   Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA   Sharakhov I.V., Tu Z.;
RT   "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT   stephensi.";
RL   Genome Biol. 15:459-459(2014).
RN   [2] {ECO:0000313|EnsemblMetazoa:ASTEI10595-PA}
RP   IDENTIFICATION.
RC   STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI10595-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CYFIP family.
CC       {ECO:0000256|ARBA:ARBA00025790, ECO:0000256|PIRNR:PIRNR008153}.
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DR   STRING; 30069.A0A182YQ59; -.
DR   EnsemblMetazoa; ASTEI10595-RA; ASTEI10595-PA; ASTEI10595.
DR   VEuPathDB; VectorBase:ASTE008574; -.
DR   VEuPathDB; VectorBase:ASTEI10595; -.
DR   VEuPathDB; VectorBase:ASTEI20_031197; -.
DR   OMA; DQPNRVE; -.
DR   Proteomes; UP000076408; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   InterPro; IPR008081; Cytoplasmic_FMR1-int.
DR   PANTHER; PTHR12195:SF0; CYTOPLASMIC FMR1-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR12195; CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED; 1.
DR   Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
DR   Pfam; PF05994; FragX_IP; 1.
DR   PIRSF; PIRSF008153; FMR1_interacting; 1.
DR   PRINTS; PR01698; CYTOFMRPINTP.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR008153};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076408}.
FT   DOMAIN          62..276
FT                   /note="CYRIA/CYRIB Rac1 binding"
FT                   /evidence="ECO:0000259|Pfam:PF07159"
SQ   SEQUENCE   1295 AA;  149207 MW;  62681D5D2B02FF53 CRC64;
     MAQEKITLAD ALSNVEVLDE LPLPDEQPCI EAQPCSVVYQ ANFDTNFEDR NGFVTGIAKY
     IEEATTHANL NQLLDEGQKH AVMLYTWRCC SRAIPQPKSN EQPNRVEIYE KTVEVLSPEV
     NKLLNFMYFQ RKAIEAFSGE VKRLCHAEKR KDFVSEAYLL TLGKFINMFA VLDELKNMKS
     SVKNDYSTYR RAAQFLKVMT DSHSLQESQN LSMFLATQNK IRDTVKDTLE KIAGYEDLLS
     EVVNICVHMY DSKMYMTPEE KHMLVKVMGF GLFLMDSEIC NINKLDQKKK LRLDRIDRIF
     KNLEVVPLFG DMQIAPFNYI KRSKHFDPSK WPLSSSTAIS PQADLMVHLP TIREDHVKYI
     SELSRYSNEV TTTYKDNATD AENKSTADLA LRGLQLLSEW TSVVTELYSW KLLHPTDHHQ
     NKECPAEAEE YERATRYNYS EDEKFALIEV IAMIKGLQVL MARIETVLCE AIRRSIYAEL
     QDFVQLVLRE PLRKAVKNKK DLIRSIVMSV RETCADWQKG TEPSQDPALK GKKDPDSGFA
     INVPRLNVGP SSTQLYMVRT MLESLIADKS GGKRTLRKDI DGSCLSQIDA FHKASFYWTY
     LLSFSETLQK CCDLSQLWYR EFYLEMTMGR KVNVSMMLAY RKCTVRHQHN EECSDLITME
     KRIQFPIEMS MPWILTDHIL RTKEPSMMEY VLYPLDLYND SALYALTIFR KQFLYDEVEA
     EVNLCFDQFV YKLSEQVFAH YKQLAGSIYL DKRFRVECEV LGFNFQSYPR NNRYETLLKQ
     RHVQLLGRSI DLNKLITQRI NADMQKSLEL AICRFEASDI TGVVELEALL SVNKLCHKLL
     SKWLALDDFD AMLKEANHNV LAPYGRITLH VFVELNYDFL ANYCYNAATN RFVRNKLQIA
     FSGPITRDKA PVMSHYYLWG SKPLNAAYST QYSQYNGFVG APHFHAICRL LGYQGIAVVM
     EIILKDIVKP LVQGNLLQFT KTLMSAMPKC CKLPLCDYGS PGVLSYYQAH LVDIVQYPDA
     KTELFQSFRE MGNSLLFCLL IEQALSQEEV CDLLHAAPFQ NILPRPFCKD GEKPESKQKR
     LEAKYASLQI VPNVEKLGTA KQAMIAREGD LLTRERLCCG LSIFEVILGR VKSFLDDPIW
     MGPPPINGVM NIDECSEFHR LWSALQFVYC IPVAGTEYMV EELFGEGLHW AGCTIIVLLN
     QQRKFEALDF CYHILRVQRV DGKDDTVKGI NLKRMVDRIR RFQVLNSQIF AVLNKYLKSN
     DIEGSNVEHV RCFPPPPHPS VAPSHYHDPN KLRTQ
//