ID A0A182YQ82_ANOST Unreviewed; 1388 AA.
AC A0A182YQ82;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI10618-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI10618-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI10618-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436,
CC ECO:0000256|RuleBase:RU003431};
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR STRING; 30069.A0A182YQ82; -.
DR EnsemblMetazoa; ASTEI10618-RA; ASTEI10618-PA; ASTEI10618.
DR VEuPathDB; VectorBase:ASTE002497; -.
DR VEuPathDB; VectorBase:ASTEI10618; -.
DR VEuPathDB; VectorBase:ASTEI20_043555; -.
DR OMA; PTDEPMC; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd14042; PK_GC-A_B; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF474; RECEPTOR-TYPE GUANYLATE CYCLASE GYC76C; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 1388 AA; 156138 MW; 630EFE062E9F7782 CRC64;
LQRSSKIPTF ARTEPPDTQV TKSIISLLTY YGWRKFSIIH EQLWKNVATS LEAQATRNNL
SVNHVEMVFD NYKCCQDDMD CCRSGYWYTV IQKTMNRTRI YVFLGNSNQL VDMMATMDGM
QLFAKGEYLV ISADMMTYSP KLSNKYLWRV EKPPNVRTCQ DLPGDFERRS RSLLVVVASE
PLPTFVNFTH KVREYTQKEP FFFKQPSLFH QFVKYVSIYA AYLYDSVKLY AWALDKLLKE
EQLHRPLTSD VIREVASNGT KIIATIINNR TYHSVAGATI KIDDYGDSEG NFSVLALKRE
NYSEANFSCE FQMRPVAHFQ MRQPQHLNDT NQHRNDEIPE FKLSKVGNAI DWPGSDRPMD
EPSCGFMNEH CMKDDTHIMS MVVAGVLALI LFCAGVITMS IYRKWKIELE IEGLLWKIDP
GDIKGYFNTE IVSSPSKLSL ASAQSFGSRC SNQVFTPTAR FRSVVVRIKE LKFSRRKDIS
REIMKEMRLL RDLRHDNINS FIGACVEPMR ILLVTDYCAK GSLYDIIENE DIKLDDLFIA
SLVHDLIKAM IYIHSSALNY HGNLKSSNCV VTSRWMLQVT DFGLHDLRHC AENESIGEHQ
HYRNLFWKSP ELLRQPNVYG SQKGDVYAFA IILFEIIGRR GPFGYTELEP KEIIDRVKAL
PEPGKEPFRP DIESVIENEN VSDYVINCIR DCWDENAELR PDFPNIRNRL KRMRGGKSKN
IMDQMMEMME KYANNLEEIV QDRTRLLCEE KRKTEDLLHR MLPQPVAEKL TKGLGVEPVS
YDSVTIYFSD IVGFTAMSAE STPLQVVNFL NDLYTVFDRI IKGYDVYKVE TIGDAYMVVS
GLPITNGNRH VGEIASMALE LLQAVRSHRI AHRPNETLKL RIGIHTGPVV AGVVGLTMPR
YCLFGDTVNT ASRMESNGEA LKIHISQQCK DALDTLGGYV IVERGLIAMK GKGEVMTYWL
EAATEQAIQK IPVDVRDLPP PLFCRPRRSP KMTFDSRHPS IIGLPGGGMM GGMGSYMPGS
RRQSCAHRVG GGADHESSYS LQGSMFGPMV PMRADSPPRR YPFDPASAGR EGSMALDDGD
DYSQCTLDQR TVPVSATTGT LGSKMASSDN LKRALFGASP ARRLSHKLRS ITSADDYKQL
CSNRSANGGR SPDAALLRES RSLDPFPVTI EPKRKRLDAL AKRVPRLAKT IAAPSRTGSQ
TFAAPTVVST ISHESIADGS SAVRRQQHDD PQQQQPRQLT ALTTKAPNNS HNSDQQSYHK
YLHNNNCNGS IGNGAGQEEQ AATCPLLTRQ TSLTTPQDHH DCPGLYTNNS SSKRWYSLEH
VGVPDEDACS KKSLTRSSIK SWLVGFIHGN GFKSSDSSLR KVGVLPVGVG GVTGFGELQP
TPEKESMV
//
