ID A0A182YR15_ANOST Unreviewed; 1525 AA.
AC A0A182YR15;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:ASTEI10901-PA};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI10901-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI10901-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI10901-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: May be involved in the metabolism of insect hormones and in
CC the breakdown of synthetic insecticides.
CC {ECO:0000256|ARBA:ARBA00003690}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR602403-1};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004174}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
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DR STRING; 30069.A0A182YR15; -.
DR EnsemblMetazoa; ASTEI10901-RA; ASTEI10901-PA; ASTEI10901.
DR VEuPathDB; VectorBase:ASTE015870; -.
DR VEuPathDB; VectorBase:ASTE015871; -.
DR VEuPathDB; VectorBase:ASTEI10901; -.
DR VEuPathDB; VectorBase:ASTEI20_037831; -.
DR VEuPathDB; VectorBase:ASTEI20_038043; -.
DR VEuPathDB; VectorBase:ASTEI20_042832; -.
DR OMA; EECYQEI; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20628; CYP4; 3.
DR Gene3D; 1.10.630.10; Cytochrome P450; 3.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291:SF105; CYTOCHROME P450 4P1-RELATED; 1.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR Pfam; PF00067; p450; 3.
DR PRINTS; PR00465; EP450IV.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 3.
DR PROSITE; PS00086; CYTOCHROME_P450; 3.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022848};
KW Heme {ECO:0000256|PIRSR:PIRSR602403-1};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR602403-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602403-1};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023033};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408}.
FT BINDING 1470
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR602403-1"
SQ SEQUENCE 1525 AA; 174388 MW; F79D7A2D32D327E7 CRC64;
MLLPVLAFIL GSCLAVLLVR DYQSKQTDGF RAAKRYPGGR IVPVLGNVLE LLFKNPVQTF
AYARANAARY GGSYRQWIDG RVILNVTRIK EAEKILASTQ HTRKSILYKF LHPLMGDGLL
CSRGAKWQQR RRILTPAFHF HILPKFLTIF QEESDKLVQQ LERFADGTQH IVLQSVVTSF
ALHTICETAM GVKLDAYDEA DQYKAKVYEV GEMLVHRTMS PWLYSDRVYR LLGYDGPLTN
SLKPIHRFTR SIIHQRRQNF QAQPTLDPDS EDNMYFGSKQ RYAMLDTLLA AEAKQQIDEE
GIREEVDTFM FEGHDTTAAA IMFTLVLLAI EQDVQDRCYA ELADLLNHSK EAPTTAAGSV
RLSVQDYQQL PYLDRVIKES LRLYPPVAFI SRTTTGELVV DGTSFPHNTI THVHIYDLHR
DPAQFPDPER FDPDRFLPEV AEKRNPYAYV PFSAGPRNCI GQKFALLEIK TVLVALLHRF
RLLPVTRPIV SSQVPPSTLL LLPGLLLLSL FIAWIVWDVI DRRGATYVSF RQFPGPAAWP
LIGTSYNTHG LDAATTFDAF RRWTQQYGGS YRLWLNSYLF SLNITRCREA EPFLSGGRNT
DKSVLYNFLH PFIGIGLLNS AGAKWLQRRR ILTPTFHFHI LTGFHRTFCE ESEKLAVKID
SQRLLEPAVE IDLQSAMSQL TLNTICETSM GVKLDSLDGA REYREGIYRV GTMMLNRAIR
PWLYVDCIYW LLGYARQLQR LLKPLHHFTN RIIAQRRELF EAGKLNDLST RTDGEHDVLY
GPGPGGSRKR YAMLDTLLAA ETQGLIDADG IREEVETFTF EGHDTTASAL TFILLTLSWE
PAVQDRLYQE VRQLHTDKGT AAPDEHLAPN DLASLKYFDR VIKECLRLWP PVTFISRTVT
EKIVLPDGRT IPQGCIANLH IFDLHRDPAQ FPDPERFDPD RFLPDRVAAR NPFAYVPFSA
GQRNCIGQKY ALLEVKTVVA YLVLRYRILP VTRREEIRFI ADLVLRASSP LKHSPLEMDI
LTVVLLFAVL LLVAFELRVQ LSAAYRAGKK FPGPKALPIL GNAHNLLFND QQRTFQLPRR
WAATYGDTYR ILVRGLLNLN AIRAKDVEPL LSSPKLIDKG LIYSLTHSFL GIGLLNSTGT
KWQHRRRILT PAFHFNILPS FLLTFQEECR RLVDQLGQYA DKGTPVALQP VATKFTLNTI
CETAMGIKLD SMTLANEYRG KIEAIGTMLL QRLMNPWLFE DFNYKLTGLQ AKLGKLLQPV
HAFTRSIIQQ RRELFHQNVR NIGDFSEENI YTNLKQRYAM LDTLLAAEAK EQIDEEGIRE
EVDTFMFEGH DTTSAAIIFT LLLLAHSPEV QQRLYDELQL VAQSRSDADG AEFTQRDYSE
LRYMDMVLKE SLRLYPPVPF ISRNISEDTL FGDRPVPKDT LFNVHIFDLH RDPTVFPDPE
RFDPDRFLPE NVAERSPYAY VPFSAGPRNC IGQRFAILEL KTVLGAILTN FRVLPVTERA
ELVFVADIIL RTKDPIMVKF ERRHR
//
