ID A0A182YR50_ANOST Unreviewed; 874 AA.
AC A0A182YR50;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|ARBA:ARBA00019081, ECO:0000256|RuleBase:RU365058};
OS Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI10936-PA, ECO:0000313|Proteomes:UP000076408};
RN [1] {ECO:0000313|Proteomes:UP000076408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA Sharakhov I.V., Tu Z.;
RT "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT stephensi.";
RL Genome Biol. 15:459-459(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:ASTEI10936-PA}
RP IDENTIFICATION.
RC STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI10936-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
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DR AlphaFoldDB; A0A182YR50; -.
DR STRING; 30069.A0A182YR50; -.
DR EnsemblMetazoa; ASTEI10936-RA; ASTEI10936-PA; ASTEI10936.
DR VEuPathDB; VectorBase:ASTE008527; -.
DR VEuPathDB; VectorBase:ASTEI10936; -.
DR VEuPathDB; VectorBase:ASTEI20_035265; -.
DR OMA; KTPSNDM; -.
DR Proteomes; UP000076408; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000076408}.
SQ SEQUENCE 874 AA; 97611 MW; 740FA96E9A0B7820 CRC64;
MPRKLQHNNN KFTSPITWVG KQYHPDINSV KLQFSAFYSK CIFGALTLEV GNYVLVSDMD
AAEPDSVDGC DVARIVHMYE VLNTDCTNMD PCRAIVEWYS RPSALPGKIN NDENYAFDPR
EVIADARFSP DISIETIFSL CCVVHVAPQV NLKELQMLKP SPNCPTFFAR YKLVKSTGRR
WNLDPLIQKP GAAVSPRKRR SMYDRSNVAT TETPKTPKLK LTRTKSMENM AILTPQQKSK
LLEDRWAVKI VDVKRNIDDV ADILSEIDIS DNEVKKTPSR QAKGRRSSMH LRLNANLNTY
ASNSGTEDEC LNYSIVRDDV ANEQHIKIKL RLSENQKNPE TPRSLRKRLP SSSSSVSHEH
VSPPKCRKSL LPSDTEHAST PTGRSHRKSI LKTPNTTGLQ HAGTPKRNIQ LSNIVEECAN
GRRVSRVLKL SPKKPDSESE PMDEPKTPKR SSRAALAASS ATKSTPKSAS KMKLIRDGTI
KPAIHSRDAP LDNQMNELAI ARERLHVSAT PASLPCREKE YEEIYNFLEG KIFDGCGGCM
YISGVPGTGK TATTTAVIRA LQHLSADEHI PRFEFIDING MRLTEPRQAY VHIHRQLTGK
TLAWEQAYNL LNKRFTTKAP RRTTTVLLVD ELDILCNKRQ DVVYNLLNWP TMPTAQLIVV
TIANTMDLPE RLLKGKISSR LGLTRLTFQP YNFRQLQEIV MARLVGMSSF NSDAVQLVAR
KVAAVSGDAR RALDICRRAT ELADDQARKT DQAVTVSMTH VTQALTEMIT SAKVRTIRSS
SRMEQLFLQA VTAEVTRTGV EECNFLGVYS QLEALAAFSG VCVPNPGRAM AICARLTASR
ILICEGGSND IYQKILLNIS TDDVHFALQA SKLL
//
