ID A0A182ZZV8_9TREM Unreviewed; 448 AA.
AC A0A182ZZV8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 22-FEB-2023, entry version 22.
DE SubName: Full=SAM domain-containing protein {ECO:0000313|WBParaSite:ECPE_0000024201-mRNA-1};
GN ORFNames=ECPE_LOCUS243 {ECO:0000313|EMBL:VDP20600.1};
OS Echinostoma caproni.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Echinostomatidae;
OC Echinostoma.
OX NCBI_TaxID=27848 {ECO:0000313|Proteomes:UP000050740, ECO:0000313|WBParaSite:ECPE_0000024201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ECPE_0000024201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP20600.1, ECO:0000313|Proteomes:UP000272942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Egypt {ECO:0000313|EMBL:VDP20600.1,
RC ECO:0000313|Proteomes:UP000272942};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; UZAN01000766; VDP20600.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182ZZV8; -.
DR WBParaSite; ECPE_0000024201-mRNA-1; ECPE_0000024201-mRNA-1; ECPE_0000024201.
DR Proteomes; UP000050740; Unplaced.
DR Proteomes; UP000272942; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF25; SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000272942};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 150..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..78
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 420..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 51449 MW; 1914C261F0C73C62 CRC64;
METSTLTLDS PALLSTQGVQ EYLCKHGVTE ANLQSIRTHQ IDGVAFCLLS DKDLLEIGIT
CVGQRKRILF ASAQYRSFVM NNFNGHLFGV RNLKNSEMFD NESGKTQVFD FCYSKHNGCA
SRGDSPGFWS EVHHDSAEHV VETNPKPWKV LVSALYLFLV AGITSFVMVI AHERLPDISK
YPPLPDLLLD NIPYIDWAFE AAEWVGVVLG LVWAVILIFH RYRCILLRRF FAISGTVFLL
RCVTMISTSL SVPGEHLAEQ CTPKAFINNT VRFHRFLEIW LGMGMSIRGI QTCGDYMFSG
HTTMLTLLNF FITEYSPRNI QVIHTFSWVL NLFGVFFILA SHEHYSIDVF VAIYVSSRLF
LYYHCLANNR ILHQEDKNRA MIWFPLFTFF EYDVCGIVPN EYEIPFRSFW LKPHSFSPRY
NHKTRSSHED VDPGADAMEL PHNHLKAQ
//
