ID   A0A183A8K0_9TREM        Unreviewed;      1015 AA.
AC   A0A183A8K0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-FEB-2023, entry version 24.
DE   SubName: Full=SEC7 domain-containing protein {ECO:0000313|WBParaSite:ECPE_0000328801-mRNA-1};
GN   ORFNames=ECPE_LOCUS3285 {ECO:0000313|EMBL:VDP69015.1};
OS   Echinostoma caproni.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Echinostomatidae;
OC   Echinostoma.
OX   NCBI_TaxID=27848 {ECO:0000313|Proteomes:UP000050740, ECO:0000313|WBParaSite:ECPE_0000328801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ECPE_0000328801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP69015.1, ECO:0000313|Proteomes:UP000272942}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Egypt {ECO:0000313|EMBL:VDP69015.1,
RC   ECO:0000313|Proteomes:UP000272942};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAN01040260; VDP69015.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183A8K0; -.
DR   WBParaSite; ECPE_0000328801-mRNA-1; ECPE_0000328801-mRNA-1; ECPE_0000328801.
DR   Proteomes; UP000050740; Unplaced.
DR   Proteomes; UP000272942; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663:SF342; FI21420P1; 1.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000272942}.
FT   DOMAIN          449..643
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          176..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          848..880
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          960..1015
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..363
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        993..1015
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1015 AA;  112291 MW;  04A25125DBFD43AD CRC64;
     MKIPDASRSC HGMSDHVDRG TATLPGLHHR ICSVNRPCTH STCHTHKRAV FDDLYVTQTQ
     AWQPLTTDLS HTDLLINENN SDKNIDSEAA NCSRNRNCRG IAQESRVYPP RTARTNSLSS
     EYVNRLQHFN PLFQQDTRKL SCPSRAPATM ELESTNGAGP LVFKCTCSHV CTQTPQARQR
     PSPRSVKAGK HTNTTNTNNF IGSSAIATDQ PVKLSCLTDP NEYFSAPAMT CLDSGCLGVR
     EFGTDHDVLG SPRPLRSDLA NAPSSVSGAR HVLVTATTAG SGNTTGNGGL VIDQNKLSRQ
     PITNHQLRIP SGSMLVAVPA SAGQFSRTHP GYVQQTLSHA PHLSHNQHPH HHHHHHHHHL
     PSAQTLGHTR NASLPHSQLV HLTTNTKSPP TCLVIPAQCH IHSGHTTVAS LSDAATSHGH
     TVQTHPPSSS SAPASAAQLQ QLALAKHQAR QQEKRRKRIY RIGLNIFNKS PLKGIEFLIK
     YGFLDCTPET VARFLLTRKG LSRVAIGDYL GNTKDELAMT TTRQFMRELD FREQEVDDAL
     RSLLSCFRTP GESQKIVHLL TEFQAAYIEQ NSARVKAQFR NPDSVMVLAY AIVMLHTDMY
     SPNVRPQSKM TRDEFVRNLR GVDAGEDLDR NLLLAIYDRI QQREMSVAPD HTDQVRKIQQ
     HLTGPLRPLN LALPQRRLVC YCRLYEVPDK NKRERPGAHQ REVFLFNDLL LITKAVQKKR
     RDAAIAYQVR VSLNLLGVRL VAFETPHHPH GLELLLPIGE SNVSLNSKES GLNPAAPLTP
     DGRARILVTL NTKTLSDRAR FMEDLQECIV EVAEMDRIRI EDEVAKQMQQ KRRLSKQLST
     AATVGNHLMS SCKSNGNHNV GSSNGSSNSL RNNNNNNTYA FMSSQNRVKM IRVLGEDRAK
     RPSDWAHARL TASALSNGKA IRAKTVPREF EAMVRRGIPS NMPMNMASGE LRETVVPRPD
     VLDTKCGPTK SSTEVPDAAE ENQRLSGDSG LLADLETPTS QCSRVLGSNT SYSPS
//