ID   A0A183AAF3_9TREM        Unreviewed;       570 AA.
AC   A0A183AAF3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=phosphoenolpyruvate carboxykinase (GTP) {ECO:0000256|ARBA:ARBA00012306};
DE            EC=4.1.1.32 {ECO:0000256|ARBA:ARBA00012306};
GN   ORFNames=ECPE_LOCUS3938 {ECO:0000313|EMBL:VDP71079.1};
OS   Echinostoma caproni.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Echinostomatidae;
OC   Echinostoma.
OX   NCBI_TaxID=27848 {ECO:0000313|Proteomes:UP000050740, ECO:0000313|WBParaSite:ECPE_0000394501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ECPE_0000394501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP71079.1, ECO:0000313|Proteomes:UP000272942}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Egypt {ECO:0000313|EMBL:VDP71079.1,
RC   ECO:0000313|Proteomes:UP000272942};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
CC       family. {ECO:0000256|ARBA:ARBA00005796}.
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DR   EMBL; UZAN01040832; VDP71079.1; -; Genomic_DNA.
DR   WBParaSite; ECPE_0000394501-mRNA-1; ECPE_0000394501-mRNA-1; ECPE_0000394501.
DR   Proteomes; UP000050740; Unplaced.
DR   Proteomes; UP000272942; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043648; P:dicarboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:InterPro.
DR   CDD; cd00819; PEPCK_GTP; 1.
DR   Gene3D; 3.90.228.20; -; 1.
DR   Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1.
DR   Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1.
DR   HAMAP; MF_00452; PEPCK_GTP; 1.
DR   InterPro; IPR018091; PEP_carboxykin_GTP_CS.
DR   InterPro; IPR013035; PEP_carboxykinase_C.
DR   InterPro; IPR008209; PEP_carboxykinase_GTP.
DR   InterPro; IPR035077; PEP_carboxykinase_GTP_C.
DR   InterPro; IPR035078; PEP_carboxykinase_GTP_N.
DR   InterPro; IPR008210; PEP_carboxykinase_N.
DR   PANTHER; PTHR11561; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 1.
DR   PANTHER; PTHR11561:SF0; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)-RELATED; 1.
DR   Pfam; PF00821; PEPCK_GTP; 1.
DR   Pfam; PF17297; PEPCK_N; 1.
DR   PIRSF; PIRSF001348; PEP_carboxykinase_GTP; 1.
DR   SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1.
DR   SUPFAM; SSF53795; PEP carboxykinase-like; 1.
DR   PROSITE; PS00505; PEPCK_GTP; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000272942}.
FT   DOMAIN          1..202
FT                   /note="Phosphoenolpyruvate carboxykinase GTP-utilising N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17297"
FT   DOMAIN          207..565
FT                   /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF00821"
SQ   SEQUENCE   570 AA;  63942 MW;  B21CFC28BE2331BF CRC64;
     MIKQLCEAGV LRKLSKYKDN YVCRTDPKDV ARVESKTFIC TPNKHDVVPH IPEGVKGVLG
     QWISPDDLNH ALKERLPSCM KGRTMYVMPF SMGPVGSPLG KVGIEITDSM YVVLCMRIMT
     RICPKVWDII QSESNFVRCV HSVGFPLPNE RTIVNNWPCN PEQTIISHIP EKKMIISYGS
     GYGGNSLLGK KCFALRIAGT IAHEEGWLAE HMLIMSVTNP QGEEKFIAAA FPSACGKTNM
     AMLQPSLPGW KIQCVGDDIA WMRFDKDGVL RAINPEYGFF GVAPGTNRKT NPNAVATCLS
     NTIFTNIAES VDGRFFWEGL EDDFDPETEV ITWLGHHVKI SDKSHDPKAH ANSRFCCPAS
     QCPIIHPKWE DPEGVPISAI IFGGRRPEGI PLVIQSFDWK HGVMLGAAVK SEATAAAEFT
     GKVVMHDPMA MRPFVGYNFG KYLEHWLGME KAGRKLPLIF HVNWFRLNDH GKFVWPGFGD
     NVRVVDWMLR RVNGEDSGEP SPIGIIPKKG SLNLSGLDVN WDDMFSLPKP YLLEDVDETM
     RYFDEQVGTD LPDVIRKELV NQRERIQKQL
//