ID   A0A183AF50_9TREM        Unreviewed;       306 AA.
AC   A0A183AF50;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-FEB-2023, entry version 24.
DE   SubName: Full=Ras-GEF domain-containing protein {ECO:0000313|WBParaSite:ECPE_0000559801-mRNA-1};
GN   ORFNames=ECPE_LOCUS5585 {ECO:0000313|EMBL:VDP75957.1};
OS   Echinostoma caproni.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Echinostomatidae;
OC   Echinostoma.
OX   NCBI_TaxID=27848 {ECO:0000313|Proteomes:UP000050740, ECO:0000313|WBParaSite:ECPE_0000559801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ECPE_0000559801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP75957.1, ECO:0000313|Proteomes:UP000272942}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Egypt {ECO:0000313|EMBL:VDP75957.1,
RC   ECO:0000313|Proteomes:UP000272942};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAN01042454; VDP75957.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183AF50; -.
DR   WBParaSite; ECPE_0000559801-mRNA-1; ECPE_0000559801-mRNA-1; ECPE_0000559801.
DR   Proteomes; UP000050740; Unplaced.
DR   Proteomes; UP000272942; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000272942}.
FT   DOMAIN          14..296
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|SMART:SM00147"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   306 AA;  35125 MW;  AC36E743FFFAE165 CRC64;
     MEPSSPFADR TDSTDKANAN ALTNTVTHEN LPIKSSTDRP SSSHSDFALP NREKHNYSCL
     PTPGTHQSEQ KAARARQLTC INLVFCHICE VLKHLKQLKN FSSFLALLLA VQEVPEILLF
     KKSKSVSDDR IEKRDFSRQV FQLLNKFSSY MKPPMFTEYR RDLEAASLPY LPYLGLIFQQ
     LIHLHAGNPK FLPDMVVQTE ADQLNRVESG NSQVLLGVMV DPTNVKEQFV NMWRCWKHYL
     ILGYFIKRME NPETARHRLP CNAEVQEILS DFKDRFSDTV LDKAKEQLIA NIKPKKSFWT
     TGSAHN
//