ID   A0A183ANZ4_9TREM        Unreviewed;       920 AA.
AC   A0A183ANZ4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=DNA repair protein complementing XP-C cells {ECO:0000313|WBParaSite:ECPE_0000870501-mRNA-1};
GN   ORFNames=ECPE_LOCUS8679 {ECO:0000313|EMBL:VDP84005.1};
OS   Echinostoma caproni.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Echinostomatidae;
OC   Echinostoma.
OX   NCBI_TaxID=27848 {ECO:0000313|Proteomes:UP000050740, ECO:0000313|WBParaSite:ECPE_0000870501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ECPE_0000870501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP84005.1, ECO:0000313|Proteomes:UP000272942}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Egypt {ECO:0000313|EMBL:VDP84005.1,
RC   ECO:0000313|Proteomes:UP000272942};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR   EMBL; UZAN01046305; VDP84005.1; -; Genomic_DNA.
DR   WBParaSite; ECPE_0000870501-mRNA-1; ECPE_0000870501-mRNA-1; ECPE_0000870501.
DR   Proteomes; UP000050740; Unplaced.
DR   Proteomes; UP000272942; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR   Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR   InterPro; IPR018327; BHD_2.
DR   InterPro; IPR004583; DNA_repair_Rad4.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR   InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR   PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR   Pfam; PF10403; BHD_1; 1.
DR   Pfam; PF10404; BHD_2; 1.
DR   Pfam; PF10405; BHD_3; 1.
DR   SMART; SM01030; BHD_1; 1.
DR   SMART; SM01031; BHD_2; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000272942}.
FT   DOMAIN          558..610
FT                   /note="Rad4 beta-hairpin"
FT                   /evidence="ECO:0000259|SMART:SM01030"
FT   DOMAIN          612..670
FT                   /note="Rad4 beta-hairpin"
FT                   /evidence="ECO:0000259|SMART:SM01031"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          773..813
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          858..920
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        798..813
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        902..920
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   920 AA;  103124 MW;  80B46F9DD463A761 CRC64;
     MCSEVRTENE KSGTMTSEDP PKRKVTAHRK RSPVICSEVS DSDEELLPNQ EQQSGSDDSY
     RPSRKKSNAG NKHLNERKHL TRSKRATDAK AESENNVVDL STPSTTNHLE DSEGSETMEA
     VKSARVRRKN KSNLLLFSEF AHSSVPKAPV EKASPVGEQS NMDDSDDEDW EDVTEETVGE
     VDIMKTLLSV QSKLEPNDAE KNVSGAAVTV SVPLHPVSQK TSNKDPAIAA AQARIRQLKE
     YHLSMHVVHV LCYLAHSRSI NLLCDSSTYR ALGLSLLGNV TSIRAGKGML LDPAEWTTDH
     LSSCLSLFLA LKSTNSNDEL QTHTTIYQRI FHGTCSTTDC AVLFVSALRV INFDVRVILA
     LTPISLRPPI SAQLNVIPEP KKQEGKQSTK AVPKINRKII SSDESDFEPT IQRRPHKSLT
     SEPDPPRYYV FAEVFLPMLN RWVCIDFYKP NGLVDKVPHY PSLFYVLGLT TTLSVNPDTQ
     PYVGRNPVDL ASRYDPDWCI RSRLHRLPAD RWSTLLDYQR VYFTRDAALN SSLVLREDCA
     STVQRDRADE DNIRSGLLAQ PLPEKMQDFK NHPLYILPRH LLKFEVIHPP DALPLGFFRG
     EPVYSRDCLH LCHTRESWLK EAKVVKPYEQ PAKVVKARAS LKRKLLQGSD PTPPMVEIFG
     SWQVEDYQPP VAQNGIVPRN AHGTIDLFKP CMLPIGCAHI CLTGELLHCH YSCSQEAVPA
     LIDAWRSTKM NAALAAAQER SERALDNWRR LVRGLFLWHR IKAQFALAPL HSDGPEAPQF
     KPARKRQTRK SKQLVHSKST SKPDSSTLDS KGLDPVTVGS LVMNKPLSQD GGWQRLGSGE
     ISQQLPIFPV ALKAPFASST NSKRQLRCQK AKPALTKQFK KSRRRKRRAN TTSEEEESEP
     TPVTSDSEKK TESSTEDSDE
//