ID   A0A183BT03_GLOPA        Unreviewed;       987 AA.
AC   A0A183BT03;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000256|ARBA:ARBA00029509, ECO:0000256|RuleBase:RU367133};
OS   Globodera pallida (Potato cyst nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Tylenchoidea; Heteroderidae; Heteroderinae;
OC   Globodera.
OX   NCBI_TaxID=36090 {ECO:0000313|Proteomes:UP000050741, ECO:0000313|WBParaSite:GPLIN_000373900};
RN   [1] {ECO:0000313|Proteomes:UP000050741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA   Aslett M.;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000050741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA   Cotton J.A., Lilley C.J., Jones L.M., Kikuchi T., Reid A.J., Thorpe P.,
RA   Tsai I.J., Beasley H., Blok V., Cock P.J.A., Van den Akker S.E.,
RA   Holroyd N., Hunt M., Mantelin S., Naghra H., Pain A., Palomares-Rius J.E.,
RA   Zarowiecki M., Berriman M., Jones J.T., Urwin P.E.;
RT   "The genome and life-stage specific transcriptomes of Globodera pallida
RT   elucidate key aspects of plant parasitism by a cyst nematode.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:GPLIN_000373900}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. {ECO:0000256|RuleBase:RU367133}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000256|ARBA:ARBA00006443,
CC       ECO:0000256|RuleBase:RU367133}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A183BT03; -.
DR   WBParaSite; GPLIN_000373900; GPLIN_000373900; GPLIN_000373900.
DR   Proteomes; UP000050741; Unassembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-UniRule.
DR   CDD; cd04886; ACT_ThrD-II-like; 1.
DR   Gene3D; 3.40.50.1100; -; 3.
DR   InterPro; IPR044561; ACT_ThrD-II-like.
DR   InterPro; IPR019354; SMG8-like.
DR   InterPro; IPR001926; TrpB-like_PALP.
DR   InterPro; IPR036052; TrpB-like_PALP_sf.
DR   PANTHER; PTHR13091; AMPLIFIED IN BREAST CANCER 2-RELATED; 1.
DR   PANTHER; PTHR13091:SF0; NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8; 1.
DR   Pfam; PF00291; PALP; 1.
DR   Pfam; PF10220; Smg8_Smg9; 2.
DR   SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161,
KW   ECO:0000256|RuleBase:RU367133}.
FT   DOMAIN          678..814
FT                   /note="Tryptophan synthase beta chain-like PALP"
FT                   /evidence="ECO:0000259|Pfam:PF00291"
FT   REGION          233..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          592..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..266
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..283
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..333
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..629
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   987 AA;  111115 MW;  8B4236E1B97105A5 CRC64;
     MEKCIESQVS HFMRQHGIID SRYPGNALGQ ITISSGAPFV YIFNHNEMPK DVNNEFAMSL
     YPEESLEEFN VEGIQKLITN VLELSPKNKD RIVGMSLYVN QLNQQPDITG GGDSAFSPLE
     HNFTLNLAIE QLIRRCPRAV GTERRKQMIE KLSEDCATLW MDGHRRCDQI SLTGQLCHFA
     MHDLPNEKAS AQSCLQDEKR PQKGHCSGVK TYSMCNCGLS QLRQREELVP IDPMTQEEAV
     MGKAFSGDDV GEEMDEHRRK ERIESTEEDE ECLDEEAEDE LSKQTGEEES SRPITPAENV
     DYLESYDVYE HGKRRSDSTE QSEKGTFGRE RTDDPKLLEK YKGRFLDHVP HSKSPPELLP
     LFPSFSVICI GHSSLYNHST GIRESPNFRS GSEFLLPWSV QLTVRTEQWL RELQFIGATP
     TERTFRNLQH HRNYERSSNM TSKEKVKLFI GFDYECPRGH RFMIAEPGKV LRHRRMSGPL
     KTDAAPLMDN DLAIWMPCPC KKEPRMSAQL MRIHIVTPKA PVSVSVQPLI QMLNDDGFFF
     PGQRERIELG WAKYYVMRLP YVYKGPSGTT FHRPNLHEFR GKLLRREIVI PPNSENTKPS
     MEELNEGTEE TSATGSLSSN TSSSASISVP ESLRVEGSDE CAIRRIPSAL CSFVDPFCDP
     KKPVKTTFSD ISSAAFNIRD GINRTPTIKS DAFSSMFDVE LFFKQEYLQV TGSFKERGAR
     FALMRLDKRA AAYHGHQLGI PVTVVMPKFA PLMKISCCES YNAKVILHGL HIQEAKIFAY
     ELAKRENIKY INGFDNPDVI AGQGTIGLEI LDQCLSSESE MCPSFKNAVE HRDEPLQPES
     SLADGLAVPT VGDNAVFMAE GLIDDLVTKA VVEGAGAVGL AAFISGKLDY LRGKRHDCIG
     GLAVDGRLIK FDIVVSDRPG GMAELTNEIG KTGASIKDLF HERAWLAANV YSVRIRVICE
     TRGEAHVQEL ITHLGKKYKQ ARMIMKK
//