ID A0A183BUT0_GLOPA Unreviewed; 1249 AA.
AC A0A183BUT0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
OS Globodera pallida (Potato cyst nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Tylenchoidea; Heteroderidae; Heteroderinae;
OC Globodera.
OX NCBI_TaxID=36090 {ECO:0000313|Proteomes:UP000050741, ECO:0000313|WBParaSite:GPLIN_000436600};
RN [1] {ECO:0000313|Proteomes:UP000050741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA Aslett M.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000050741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA Cotton J.A., Lilley C.J., Jones L.M., Kikuchi T., Reid A.J., Thorpe P.,
RA Tsai I.J., Beasley H., Blok V., Cock P.J.A., Van den Akker S.E.,
RA Holroyd N., Hunt M., Mantelin S., Naghra H., Pain A., Palomares-Rius J.E.,
RA Zarowiecki M., Berriman M., Jones J.T., Urwin P.E.;
RT "The genome and life-stage specific transcriptomes of Globodera pallida
RT elucidate key aspects of plant parasitism by a cyst nematode.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:GPLIN_000436600}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR AlphaFoldDB; A0A183BUT0; -.
DR WBParaSite; GPLIN_000436600; GPLIN_000436600; GPLIN_000436600.
DR Proteomes; UP000050741; Unassembled WGS sequence.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 3.40.960.10; VSR Endonuclease; 1.
DR InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR33568; DNA POLYMERASE; 1.
DR PANTHER; PTHR33568:SF3; DNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF03175; DNA_pol_B_2; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 198..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 826..1005
FT /note="DNA-directed DNA polymerase family B
FT mitochondria/virus"
FT /evidence="ECO:0000259|Pfam:PF03175"
SQ SEQUENCE 1249 AA; 143128 MW; 41CDD81069EDB745 CRC64;
MSPPPAKRTR RFFIEDILRE PYNELSPPQK TAQDYVKKLD NEVEQASKFQ WVKTKSRFSI
TDVPADPEGL LAGIFQHCVD GGLDESRQRG VEPTHLGCTI SSQLLSSDIW IPVRQITEDT
INTILNRFND VAQSKKQDGV TLWGEPFTVS VTTVNRNGLN VRRLKGGAPR KLAPVHHRIS
AKSLININNN NDGNNYCLFY AMMATLMHAI GGLTSLQFFY YLHSQKGMRG KLQQDTMEMM
NVVNAPPGQQ SYDAEIYAPR VIDWWNTQKF VDQFKFKAFI FGSSGQYKPL FKYGPEEYEV
PIILYFDDGC NKMFFNDNCR QHHLTTNFCK RSKECKDCGK VYDVYDTTRG GREGHKCHEK
WCENCQIFHD LKRGCYIKPL DGNEKKEASG WRLVTFDLET MQHEPADPDF PEQRKHQVNF
ITAKVACPEC ISSGEWKKSL CGKECQICGP NRVITFSQKP FRDTDVDKQI VTRHPLVDFV
KWILYELPIK FETVAYSHFG GRFDMVLVFR EIFMEGLNPT MIRKGNRLFE MTVTKRKNVN
PQVSFRDSWN LVPGPLASMV PMFALDVQEK PFFPHLSNQP ANYGRLIHPS KADYLADGMM
PEKRKQFDRC YCKNDVDILM SGLVAFRSEF LELTKRKAGP DGKAERATFK NPHNGIDPVR
DCITIASACM RHFRTNHLKP GHLALVPEKG YDSCGDNQSD LALAFMDWYA EEHGVRIQNA
FSADGEKRVG NFRLDGWIEE QQKGLEIHGC VWHACPRCYP DEELEMPNGK TAGRIRERNK
MRMDYIKSQF PDIEIFWECD IRSMLVRDKQ MKEKFDEFTG EGGPINIRGC FMGGRTGALK
LYHQAASNEE ISYYDFTSLY PFINFVTTYP VGHPKLDVPC EEVDWRRPED NPYPLAILKV
FVIPPRQIDV PVLPVKVNDR LCFPLCMACC KKYPSGAVMD SYSCTHNDKQ RGWISTCTSL
ELNAALEEGY RVTDLLRVLE YSKGDNKLFR PYISEFIAQK MHASGFDEEI RGNFQAEEQF
IGECLEKFDI KIDRSKMIPN KGKRSLAKLG VNNLWGRFSL RNFGLSKTLI TDDPGVLGNY
LDNRKIEITA LDMLTPEVIL ISYVEKKEWI KEHPCSNVVI SLFTTSAARL HLLKSMQKVV
RSPGCTLLYT DTDSLVYAHP KESNPLQTGP HLGQFTNELP KHEIAEFVSG GSKQYGLKLR
KKDAPPDSNY EYILKVRGMT LNHDVMNNQG KGIVCSRDFR VLDFGHIEP
//
