ID A0A183CMA4_GLOPA Unreviewed; 2259 AA.
AC A0A183CMA4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Interference hedgehog {ECO:0000256|ARBA:ARBA00041099};
OS Globodera pallida (Potato cyst nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Tylenchoidea; Heteroderidae; Heteroderinae;
OC Globodera.
OX NCBI_TaxID=36090 {ECO:0000313|Proteomes:UP000050741, ECO:0000313|WBParaSite:GPLIN_001401000};
RN [1] {ECO:0000313|Proteomes:UP000050741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA Aslett M.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000050741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA Cotton J.A., Lilley C.J., Jones L.M., Kikuchi T., Reid A.J., Thorpe P.,
RA Tsai I.J., Beasley H., Blok V., Cock P.J.A., Van den Akker S.E.,
RA Holroyd N., Hunt M., Mantelin S., Naghra H., Pain A., Palomares-Rius J.E.,
RA Zarowiecki M., Berriman M., Jones J.T., Urwin P.E.;
RT "The genome and life-stage specific transcriptomes of Globodera pallida
RT elucidate key aspects of plant parasitism by a cyst nematode.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:GPLIN_001401000}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
CC -!- FUNCTION: Mediates response to the active Hedgehog (Hh) protein signal
CC in embryos, functioning upstream or at the level of patched (ptc).
CC {ECO:0000256|ARBA:ARBA00037573}.
CC -!- SUBUNIT: Homodimer. Heterotetramer; 2 iHog chains bind 2 hh chains when
CC facilitated by heparin, heparin is required to promote high-affinity
CC interactions between hh and iHog. {ECO:0000256|ARBA:ARBA00038530}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. IHOG family.
CC {ECO:0000256|ARBA:ARBA00038144}.
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DR WBParaSite; GPLIN_001401000; GPLIN_001401000; GPLIN_001401000.
DR Proteomes; UP000050741; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 6.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF53; BROTHER OF IHOG, ISOFORM G-RELATED; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1088..1112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..138
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 146..275
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 276..362
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 388..476
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 482..599
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 604..719
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 729..819
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 852..943
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 945..1049
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 528..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1271..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1370..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1597..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1665..1698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1747..1847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2084..2103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2115..2136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2237..2259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..550
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1288..1331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1599..1630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1665..1697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1767..1803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2117..2136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2259 AA; 243908 MW; D887E4C6534DB287 CRC64;
MPVDEGQYQC AVHVITQQQQ HQHTGADQHG KESHWIFLSR RASLSLPSLH RFEQQPTDQH
ARIGQMAAFR CLLNSKPLAQ IEWHHDNRLL KNGEGGYLVL PVSQTLEISH VRSEHAGVYK
CVARNGDRSR TSQLGTLTVL DGEESPQSMH WVLEPRNQLV TVGDSVLLEC LANNGGARQS
TKIQWLHNSE PLASSAIDGG KPLNNNDDGA AAAAAAADVA PSSSSTSSVF AMVGRRRTHL
LIRNVSAQTA GQYTCRAQNA LRTQDVGATV AVRVSPTITI RPVDVLTQET NDVEFECVAE
GVPTPRITWN KNGEVIIPSE YFVIASNKLR IFGLVRDDQG VYQCIADNEV GTEQAAAQLL
VDQAASHLPL ISPSSDDSVR ALVVPKTPAQ ALSLRATDTG AQSVQLRWDA PLNNQKFGPI
THYIVAYREE GSTSSDTQQT LDNLRPQTSY SVRVIAVNLV GPGTPSDALL ITTKKQESLP
GKVRSLRAEV LSSESIQVQW DEPTPIDASS NLDIRYKLFY VKVAENVTGH ENEEDTEEDD
DDDEDGDDAS SETQVLMVKT SYTLHGVAKN APYSIRVEAE NVHGAGPSSE PFVVRTWPDT
PSAPPRDVQA DSLPQPGHAI RVRWRPPPRA QWNSDALIGH KLRYRMKGGR PPGGGKATAS
TVLVEEEEGE DDDDGMEGWW THTLDGLEPG SPYLIRVAAV NQNGTGPWTD WTAVDTPEEQ
KEESQISGAP SELRVLASHD SVQVSWLPPR DDNVLIRGYL VGWGINIPDV EKATVEPEVR
HFTIRGLKPN REYVISLRAF NRIGHGFPIY ETVKTSSYGV HSSSVSSSSI ADPKPTFGGF
GHQNDNANSL PAPVGVVAEA ISSSQMRLTW IDPNENAFNQ LYTIKYGMSN TDEAQYKLLN
STETEHTFDG LRPDTLFEFA VRLAQSPHWS LNAVNRTFPA PPSSPPRDLT VIGPQSGRPH
EDSDPSMVTL TWQPPKYANG EIQEYIVLYS DRPNLPDRDW VMDSVKGDRL SIAMRKLRPD
RIYHFKLQAR NVKGYGPFTP VASFTTATTF PPFGGADPNR SSVDDDSDSN TSAAILFGQF
FDGMRSNLAF VLIGVVVVVV LLLVVALLAA CFQRSKNDHN VRASATMSNR SQRRHKKQRN
RSQQQSYIPG RKMSVSTPSA VAELDDDLWM IHQQPQQHNA GGGGGRFATL INASAIEDFE
SAATVDDGTG ILLIDGQQRA FIAPSGAAGL NLQSAAMECL TPAHYQQAFH AATTQRQETE
HGQLEGGVVE VAFGGGSVPP TSLPHGMLES FHSMTNPATP AEQSPKSGGS TGTKRRNQHR
NSLPPHICPS SSAKISPIVA QKCQQLHHHH HHQQHDHLQN VAARGGEKTT VNFGRQSNSP
AADTRPDHQR VATVRMHCGS GGRISKSSLN ALDLSISPCL DCYHECYHHS ASYSPAAHSS
TPKIADHQQN NVAETESLNK TNNAVPRQFQ VGISLPSMAL QVKQAKRTAT ANYEPTTRRH
MAPVKSVNFA SKLVIVSASD DDECETETAP TTAQCRRRNG NINEDKIAFI DDIGISNVED
GIGDEHARAG HGRVDAGGEA DYDDDEDEAN CMIKRKKATA TTPAQNHSGN NKQNDYGGRT
VPSLSPAGFA MNSVGTLPRG HPNHHQHLHN SSASLEMKSA PQPLHLHQQQ QNHYVQQQHQ
QQQQQQQLGN TPLTPRNPHV VYTRVNRQPI AKVDFSMNGA ATAAATTTVP PHDSPHYQQR
HQFVGGAVSS ASAAGGTPPL PAPPSSSLTG ACASRTATTT SSTTIISNHP QHNRNSSEGG
YQTVGGGRGN CGTMRSFVDA GTTEDDGNGS CEALPVPSTG EQHHEQQQQQ RMAHIVRPIV
YAGGCGGGGG IAGGASPSPS TLRTHKFTYN NNGAKVPVGR ATAQPRVNLA TAAVAAAANL
PSDVTALNAL DLSISPCLDC YHECYHHSAS YSPAAHSSTP KIADHQQNNV AETESLNKTN
NAVPRQFQVG ISLPSMALQV KQAKRTATAN YEPTTRRHMA PVKSVNFASK LVIVSASDDD
ECETETAPTT AQCRRRNGNI NEDKIAFIDD IGISNVEDGI GDEHARAGHG RVDAGGEADY
DDDEDEANCM IKRKKATATT PAQNHSGNNK QNDYGGRTVP SLSPAGFATH KFTYNNNGAK
VPVGRATAQP RVNLATAAVA AAANLPSDVT ALYGYSAASP SQYANVRAAA AAANAVNTGG
TKNSMEHGGG GGELYINNNN ISSSKTIDST EDLEEIDHM
//