ID A0A183DU45_9BILA Unreviewed; 621 AA.
AC A0A183DU45;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=26S proteasome regulatory subunit 8 {ECO:0000256|ARBA:ARBA00040909};
GN ORFNames=GPUH_LOCUS12236 {ECO:0000313|EMBL:VDN20102.1};
OS Gongylonema pulchrum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Spiruroidea; Gongylonematidae; Gongylonema.
OX NCBI_TaxID=637853 {ECO:0000313|Proteomes:UP000050760, ECO:0000313|WBParaSite:GPUH_0001225001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:GPUH_0001225001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN20102.1, ECO:0000313|Proteomes:UP000271098}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
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DR EMBL; UYRT01079155; VDN20102.1; -; Genomic_DNA.
DR WBParaSite; GPUH_0001225001-mRNA-1; GPUH_0001225001-mRNA-1; GPUH_0001225001.
DR Proteomes; UP000050760; Unplaced.
DR Proteomes; UP000271098; Unassembled WGS sequence.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032501; Prot_ATP_ID_OB_2nd.
DR PANTHER; PTHR23073; 26S PROTEASOME REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR23073:SF166; 26S PROTEASOME REGULATORY SUBUNIT 8; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 2.
DR Pfam; PF16450; Prot_ATP_ID_OB_C; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU003651};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000271098}.
FT DOMAIN 214..300
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 302..441
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 34..101
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 621 AA; 69189 MW; E06A1F8F6964E630 CRC64;
MVPPIAGSIM MAPCAAAKCN SEEQSLKRYY KTKIEDMQQR VAEKTQNLRR LHAQRNELNT
KVRMLKEELQ QLHEQGSYVX XXXKLLMVRM LKEELQQLHE QGSYVGEVSK AMDKKKVLVK
VHPEGKYVVD LDKGVDISSV TPGCRVALRA DSYALHKVLP NKVDPLVSLM MVEKVPDSTY
EMIGGLDKQI KEIKEVIELP VKHPELFDAL GIAQPKGVLL YGPPGTGKTL LARAVAHHTE
CTFIRVSGSE LVQKFIGEGA RMVRELFVMA REHAPSIIFM DEIDSIGSSR VEGSSGVNIL
CGLQGVLLYG PPGTGKTLLA RAVAHHTECT FIRVSGSELV QKFIGEGARM VRELFVMARE
HAPSIIFMDE IDSIGSSRVE GSSGGDSEVQ RTMLELLNQL DGFEATKNIK VIMATNRIDI
LDPALLRPGR IDRKIEFPAP DEKARADILK IHSRKMNLMR GINMKKIAEA IPGASGAEVK
AVCTEAGMFA LRERRIHVTQ EDFEMAVGKV MDHLKPXXXX ILAWRIDRKI EFPAPDEKAR
ADILKIHSRK MNLMRGINMK KIAEAIPGAS GAEVKAVCTE AGMFALRERR IHVTQEDFEM
AVGKVMQKDS DKNMSLKKLW K
//
