ID A0A183DWX7_9BILA Unreviewed; 512 AA.
AC A0A183DWX7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Anticodon_1 domain-containing protein {ECO:0000313|WBParaSite:GPUH_0001323301-mRNA-1};
GN ORFNames=GPUH_LOCUS13218 {ECO:0000313|EMBL:VDN21869.1};
OS Gongylonema pulchrum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Spiruroidea; Gongylonematidae; Gongylonema.
OX NCBI_TaxID=637853 {ECO:0000313|Proteomes:UP000050760, ECO:0000313|WBParaSite:GPUH_0001323301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:GPUH_0001323301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN21869.1, ECO:0000313|Proteomes:UP000271098}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC ChEBI:CHEBI:456215; EC=6.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000114};
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DR EMBL; UYRT01080019; VDN21869.1; -; Genomic_DNA.
DR WBParaSite; GPUH_0001323301-mRNA-1; GPUH_0001323301-mRNA-1; GPUH_0001323301.
DR Proteomes; UP000050760; Unplaced.
DR Proteomes; UP000271098; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033709; Anticodon_Ile_ABEc.
DR InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF19302; DUF5915; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000271098}.
FT DOMAIN 1..38
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 89..238
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 512 AA; 58049 MW; 5D368B0BD8AEE173 CRC64;
MSKRLKNYPD PMEVVGTYGA DALRVYLINS PVVRGENLRF RESGVKDVLK DVLLPWYHAY
RFFVQNVQHY EDFCHKEFAL IDRASNVMDS WILSFTNSLL NFVQKEMSEY HLYAVVGPLT
KYFDTLTNWY IRLNRLRIRG DAGVEQCELS LSTLGRVLLL IVRLMAPFTP FFCDHLWQNL
RHISSSGSES VHFESIPQPR DDLICESLER SVAAMRTVID LVRFLRERKT IPLKYPLKSL
VVVNRSKQFL DDVISLQKYI LSEVNVRKLT VSQDKEKYGL HLKATPNFRV LGAKLKGDMK
KVINYLKDKV TDEELESFAE KGVLTVLGYD LSHEEVNLSY ISNVMNASGE ECAAHSDGQA
NLMSVDKATA YCEVDPPTHH LSDVIISHSE YIENITSTPV VLSALPEATT PIATFSSAVK
DATLKLYLVS EKPCAAAPTI MVHYGAEERR ILLQAGDMTL TYNRLLYEIR ALFSLWSKPK
LLLSLEPPPA SSFLSSTSSL VELANKTVYV IT
//
