ID   A0A183E4J5_9BILA        Unreviewed;       417 AA.
AC   A0A183E4J5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=transketolase {ECO:0000256|ARBA:ARBA00013152};
DE            EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
GN   ORFNames=GPUH_LOCUS15886 {ECO:0000313|EMBL:VDN26870.1};
OS   Gongylonema pulchrum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Spiruroidea; Gongylonematidae; Gongylonema.
OX   NCBI_TaxID=637853 {ECO:0000313|Proteomes:UP000050760, ECO:0000313|WBParaSite:GPUH_0001590801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:GPUH_0001590801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN26870.1, ECO:0000313|Proteomes:UP000271098}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|ARBA:ARBA00001941};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; UYRT01083039; VDN26870.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183E4J5; -.
DR   WBParaSite; GPUH_0001590801-mRNA-1; GPUH_0001590801-mRNA-1; GPUH_0001590801.
DR   Proteomes; UP000050760; Unplaced.
DR   Proteomes; UP000271098; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   CDD; cd02012; TPP_TK; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR049557; Transketolase_CS.
DR   InterPro; IPR005474; Transketolase_N.
DR   PANTHER; PTHR43195:SF1; FI06132P-RELATED; 1.
DR   PANTHER; PTHR43195; TRANSKETOLASE; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS00801; TRANSKETOLASE_1; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271098};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          14..272
FT                   /note="Transketolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00456"
FT   DOMAIN          313..389
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02779"
SQ   SEQUENCE   417 AA;  45769 MW;  C5B3A247CE2786AD CRC64;
     MVGEKVEALE LYDMANRLRI SSIEMTAASK SGHPTSSCSA AEIVATLFFG EMKFDKKQPK
     NPSADRFVLS KGHACPVLYA VWHELGHLTR DDMMSLRKLG SDIEGHPTPR LDFIDVATGS
     LGQGLSCAAG MAYVGKYIDK ASYRVYCLLG DGECAEGSVW EAVGFASYYK LDNLVAIVDM
     NRLGQTQQTM FGHDADALAK RFEAFGCHAI VVDGHNVEQL CDAYKSARET KHRPTAIVAK
     TFKGKGIVGI EDENNWHGKP VPLDTIEPIR QLIVQKDDQL KLTNKTPIMD APDVHLPIGK
     IKMAPPDYKV GEKVATRMAY GTALAKLGDV CSRIIGLDGD TKNSTFSEKL LGKHPDQFIE
     CFIAEQNLVG VAVGLQCRDR AIPFARYFFF SAFDKVLRFL CKDPNLGLSA LSYIAST
//