ID A0A183GYA6_9BILA Unreviewed; 2667 AA.
AC A0A183GYA6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Ig-like domain-containing protein {ECO:0000313|WBParaSite:OFLC_0000021501-mRNA-1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000021501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0000021501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 387005.A0A183GYA6; -.
DR WBParaSite; OFLC_0000021501-mRNA-1; OFLC_0000021501-mRNA-1; OFLC_0000021501.
DR Proteomes; UP000050787; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR45836:SF4; PROTEIN SLIT; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07699; Ephrin_rec_like; 6.
DR SMART; SM00181; EGF; 13.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM01411; Ephrin_rec_like; 7.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2416..2434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..114
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1378..1417
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1457..1492
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1494..1534
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1536..1577
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1579..1616
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1617..1653
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1655..1695
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 2646..2667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1382..1392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1407..1416
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1461..1471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1482..1491
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1524..1533
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1567..1576
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1606..1615
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1643..1652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1685..1694
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2667 AA; 301692 MW; FADB44E3AB99FB77 CRC64;
MTVFYHLEDS KRNQSDESNA MMNRYSKNCI INTVNDVHVN VNTSAMLWCF LSANCTNITS
ISDSFQIKWY RNNYQNISGI SLKGKNGSWG LFFESVKNSI VLILQLNDNG RYYCALLDKK
RGVLEKHPAD LYVYQTFETG RSWPEIVQNS EPVKEILFTT DNNDWSIISE NISMEDISIV
NGTKPTNKYV FIAMHLISKK ERKKMLYAKN KFFNSMRIAY CRSWLFQQVV LLPGGCYVME
IKYQSENCST CSLELISHSV ENTDLANYSL AYSNETNIVL IDHGFNFFQK EICLQQSNLF
VGIRGDVNSM VLDSVKIYTI KCPEHLNLWH YLFFLRLQLN KKKVETLFYK ANIDSLRCWL
LGTSELYTVP TNNCHGTIVF GQCLHGARTI VQGQTPELFC TQHGKWIYNM QNANLCFCST
NYTSEYDACV ERGPVCYVCS GNVGTDCNDS SAVFCDKRQY CFTQITKFLG GNIVRKGCIN
ECFANPVGCT TKEEACEMCC QEDYCNSWLN MSKIHNEYLR PYPMFRAICP RNITVLRYSK
GLFAAAAIVP PLIYNYEPFY HLTVDQNIFN GTVQLIKEIN AIVWTVTNRM SQFRNCSTYV
SYKDYWAPVL DCPSLYIDFL ANTTSLKFRS RFPNIDYRDL GSRISLHYAP SNGTIAEIGE
PVKVTVTATD ESNNSAQCVF WYIGQVADCP LWPINETEYE CKGSMNQRIC KRRQKCSGIQ
FPHHITALHC VAGQGWSYMS PQSIAVVPMN LFRLPVCLRN SANDVHLSMN LATNSSLNQS
CKAALIHKIQ QLPKMHEAEN CRQLNWTFTG LLVVHNNIFV NYTMRHENTS TTFKCAAQFV
RQIIKGKLAF NALKSTCKNI QFNALSANYS NGCFKDECAP GFYAAANGCY PCPLHTYSET
IGAKNCTRCP KNTFTSKTGS FSSQLCQKKC PPGFFSPTGL EPCQACAVGF YQPFFGSQSC
NNCISPRKTS AVGSVSASDC CKPGWFSRTG FEPCMKCPIG FYQDRAGQTT CIACIINANN
KQISVNHCKG FFCTESGCKN NGKCSNGRCI CPFFHIGLDC TVALNLCLAN FCPRSEECHF
DGVITSCIYN GDPSSEVSRM IWWESLWKLK QQKQQKQLLD EETQKVVNKS SLLASKRLAN
ILAKLNTDSG LIDKEFSVWS KNARIRREAN KETIISTGSH SSISDPTQPF MQFISDHLTS
SEIATTGEWK SDLSHTTKLI KTFSSSLIKM SNHGRDNVES TTPISTVLTV INATSSIPQI
RCSDRLNFCK NGNCATSSNG SISCICQKGY KINGSNYCVL LQSCDYNPCG QNICKNINNE
YFCQCSVAHN IFHQQKWCPI GKECDQKNLC KNNGISICDY KSRCICPTSY YGEFRSEKTE
PCKNLPCDHG ICISQFDQLL PYYFCRCDPG YYGERCTAHA VCTDRNINCK HGYCHKNDDT
ANCKCYPGFT GSDCSEEINH CNSSPCVHGT CKPKFLGYTC ICDEGYKGNR CENLIDPCDE
KPCNINSECR ALSYGYRGKF LCNCAAGWTG KYCTELIDLC IHSQCISGST CITRPGVNGE
VSYVCICPPN KAGIFCNESV DYCKPMNPCL NKGICQGRDD GYTCHCKPGY QGDHCQYNLC
SPNPCQNNGN CTILSLTTYN CSCPQYYEGV NCTVVTDACA ASNFDDYCLN GGKCISNNFE
PVCRCTYQYE GRRCENKKDL DFNVIFNKQT RNLRSTPFDS SVLKQFTLCF WIRMISIDNS
SFVSFLNFDQ QGFGQKVLSI TKKVVKFGKY IGLTNMAENE WQQFCLRKKK DGTTEWIRNG
EIVWKRKWDM PPINGSLRIL LGALGSFHGE MSMVQLYRVA LSSKQINNSI HHCKQWLQSI
ITSNETPLID WNHFIGVKRG NRNFPAICTI SECVLNPNSC NSTIDKVPPK IINCPADIKI
TSKDRLTVVN WFPSKSNEIF ADNDIINMGK YHIVYIAEDR AGNIETCQFN LIIATMNCSN
PEKTVGINFT IRNVHSENVQ KVACVECEAN YMPIHPITDF YFCDLMGQWT RWPHGVNFYF
PSCLKYQAPL QQLSGLVTVT ANCNELEMYE KNLTTVILNA NKQFNHFCTT LNCTNELKIW
SNSSCNSRIL RWFNKSNENI DLYYSIAVNI TRKSIKSIVI ENLNKIFGNN TGNTRMSWQC
PSKNYPAQIF GHDTRSCVKC PPGMYCVNDK CMPCPENTYK KDSGCKQCIP CPNNTITGPI
IEDIGYQTNC SAGFHYSIQE GSCVECPKGM YQDQPGQLRC NACPEFRSTL KRGSVHVSNC
TVTCGAGMSM NAQSTCVKCA KGKYRLENSS EVRCTPCPDY FTTPDNGSVD QSNCTVLDCP
PGTYINLSSP SECFFCPRNY YQEKSNQTEC RKCMKSLITL GTGSVHPRQC MKPLFWNPVV
SDVDISKHFT SSRRPIFGFI CFICAIAFLA LLYFQRQRIR TLFCKIRKTR LKHVATQNYY
RDSSFTYPIV TITPADISAT HDFIEDIVPK NPEPQEMVEI YQEIYDGLHS MAEGTSRMSN
NELASNQCFR SISRVRLEVD TTLKAEFCGD PKARGMDSSG FPIDSADYEY ADQCKSMDPE
NYGQNLQASA FEENQTSRFQ QRFDAYRNWN LRIPLCEMYA EPTEYKLFLP GTSNISIKET
NGILRDENKN EENKDEESDD EVYIVKT
//
