ID A0A183H0F3_9BILA Unreviewed; 530 AA.
AC A0A183H0F3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN ORFNames=OFLC_LOCUS963 {ECO:0000313|EMBL:VDO27728.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000096201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0000096201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO27728.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; UZAJ01000399; VDO27728.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183H0F3; -.
DR STRING; 387005.A0A183H0F3; -.
DR WBParaSite; OFLC_0000096201-mRNA-1; OFLC_0000096201-mRNA-1; OFLC_0000096201.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF28; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 6.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..52
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 131..173
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 173..200
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 58018 MW; 9B82B1318ADD9A37 CRC64;
MTESRQTQYK NMGKDSEALR KNRMENIVSI RKDKREETLS KRRNIPADYG FVVNNEVEKS
LGQARSLDSD DASTSAGGVV VNGTYNRNTL EDIVKKASSQ DQEVQLSAVQ QARKLLSSDR
NPPIDDLIAS GILPILVQCL SSNNVTLQFE AAWALTNIAS GTSQQTQSVV QAGAVPLFLE
LLSSGNMNVC EQAVWALGNI IGDGPHFRDY CIQLGIVEPL LKFITPGIPI GFLRNDPPPS
PEIVQTLLPA LAALISHTDQ NILVDTVWAL SYLTDGGNEQ IQMVINSGVS YLVVSNLIPL
LSHPEVKVQT AALRAVGNIV TGTDEQTQLV LDCGVLQQMP ALLSHQKEKI NKVKCFFSNE
AVWFLSNITA GNQAQVQAVI DAGLMPMIIH LLEKGDFQTQ KEAAWAVSNV TISGRAEQVE
YMVSQGVIPP FCALLSIRDS QIVQVVLDGL NNILKMAGPR SEAICTMIEE CGGLDKIEHL
QNHESEEIYK LAYEIIDNYF SETDDDGIAT GDHFFESTQQ NVPSEGFSFQ
//
