ID A0A183H205_9BILA Unreviewed; 995 AA.
AC A0A183H205;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=RasGEF domain protein {ECO:0000313|WBParaSite:OFLC_0000151401-mRNA-1};
GN ORFNames=OFLC_LOCUS1515 {ECO:0000313|EMBL:VDO29821.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000151401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0000151401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO29821.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UZAJ01000727; VDO29821.1; -; Genomic_DNA.
DR STRING; 387005.A0A183H205; -.
DR WBParaSite; OFLC_0000151401-mRNA-1; OFLC_0000151401-mRNA-1; OFLC_0000151401.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 79..273
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 324..444
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 494..681
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 746..994
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 995 AA; 116059 MW; A776A20228BD4E60 CRC64;
MLYLLSVIEY IAADILKWTG NYVKNIRKCD PSIGLQNLKI ALSADTSLME LTEMLYNEEE
TSTTGILNDN VEDIVQEMSY EEASRDFNRE EAQYLRDLNL IIHVFRRRFE TVFDDSDEHY
LDEIFGNILE LHELTVKVQR MLEDAIEMSD TPCVGAGLWE LAEAHEFDVY IAYMDLFKRP
LTTVIEKVLN DAKYEQFFML EDRAHSITPG GKTFRLAVKY VLPSLLEIPV VHFFRYVELT
NILCHLARPP DEVEDLRSTK SYFGGLAVKI ESLCPSFLIN HLKTEQSVRA LQESNCSRQR
RRIQEIQRSI ELWEGKEIGY RCAEVIKEGD LLLLRSGPLS STDTLKKNRG TTMRHTFLFD
HLLVFCKTLR SSKPEKPLYK FKDKVLIRKT DIFDLKDTEE LQNSFKIVSR SITHDRGDNF
SWILFCRTPE EKTSWMCDLV KIQAKSSLDR MLDASLKEEE KRVPLILPTS DQYRFADQDC
DENIVFEDYT SSSGIPVVKH GTVLKLVERL TYHLQNEVIS ISNIHVFRYT DYNYVRTFLT
TYRSFCTSSE LLQLLIERFE VPTPPQLQIA ETNNISDLES RELLNGPYAT VHSQGLRNQV
SPTLLNRIER SYQRFRKEYQ QPIQCRVLSV IRQWVNNHWY DFEHNPVLLH DLCSFLEETD
SHGKVINQYK KWCKSIKKRA DAIPMTHNGL EIEPSLLTTT LYGPQKPKAR IYTVVFHLVL
IDFFFQILWH IAEKGAIETY DLLSLHPIEI GRQITLLQFD LYKAIKPIEL VGSAWTKRDK
DLRSPQLLKL IDHSTMLTYW VARSIVETVS LDERVYMFSR VLEVMSVFEE LNNFTGLVAL
YSALNSSSVY RLKACWERID REKQIWYEKF KKLCNPHWKE MIERLKSINP PCVPFFGHYL
SKIFFYEEGN STFVQSEDLT HDQINAEGSM SIVGATGRKV MVSFVKCRRI ASIISDIQMY
QNEPYALEVE PSVRVSDFIR FIESMVNFMG VLSSS
//
