ID   A0A183H2N0_9BILA        Unreviewed;       425 AA.
AC   A0A183H2N0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=ANK_REP_REGION domain-containing protein {ECO:0000313|WBParaSite:OFLC_0000173901-mRNA-1};
GN   ORFNames=OFLC_LOCUS1740 {ECO:0000313|EMBL:VDO30619.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000173901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0000173901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO30619.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UZAJ01000877; VDO30619.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183H2N0; -.
DR   STRING; 387005.A0A183H2N0; -.
DR   WBParaSite; OFLC_0000173901-mRNA-1; OFLC_0000173901-mRNA-1; OFLC_0000173901.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR024862; TRPV.
DR   PANTHER; PTHR10582:SF2; INACTIVE; 1.
DR   PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR   Pfam; PF00023; Ank; 2.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          161..193
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          217..249
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ   SEQUENCE   425 AA;  48712 MW;  35EB9D63D027E93F CRC64;
     MGQLKSKILH QAGAENIDNL KEDPDDQWSN LYRELTGGEL IAAFEKEGED GVLKFANEKL
     ISMMYEDGAS PQMIRFTDYA KWKKTTNVQL GKTESNFVGQ FGSKFREHLG QWRLNKRGVE
     GETIIHLLLN REEPMCSEIA RILITRYPGL ANDIYLGDEM FGQSALHLAI VHDDYETVHL
     LLQNSAEVNA RACGTFFLPE NQKTSRKSTD YQGYAYYGEY PLAFAACFGN KDIYDLLIQY
     GADPNLQDMF GNTILHIYAV RHWAKPADPN IVNAAGLTPL TLATKLGRKD IFEEMLELMK
     VVRTFTEFWR FSDMTCSAYP LTALDTIRPD GSTNYDSALM TVINGSTGEH LDMIGSEVIQ
     RLLADKWKAF ASRKLFERLG LLILHLIFLC FVVYMRPTDP ERLMYKLYAT EWNDWVYYFH
     CFAFL
//