ID A0A183H3M3_9BILA Unreviewed; 538 AA.
AC A0A183H3M3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE SubName: Full=Rho-GAP domain-containing protein {ECO:0000313|WBParaSite:OFLC_0000208201-mRNA-1};
GN ORFNames=OFLC_LOCUS2083 {ECO:0000313|EMBL:VDO31810.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000208201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0000208201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO31810.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004481}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the VTA1 family.
CC {ECO:0000256|ARBA:ARBA00007895}.
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DR EMBL; UZAJ01001127; VDO31810.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183H3M3; -.
DR STRING; 387005.A0A183H3M3; -.
DR WBParaSite; OFLC_0000208201-mRNA-1; OFLC_0000208201-mRNA-1; OFLC_0000208201.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.420; Immunoglobulin FC, subunit C; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.25.40.270; Vacuolar protein sorting-associated protein vta1; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR044538; Vta1-like.
DR InterPro; IPR039431; Vta1/CALS_N.
DR InterPro; IPR023175; Vta1/CALS_N_sf.
DR InterPro; IPR041212; Vta1_C.
DR PANTHER; PTHR46009; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG; 1.
DR PANTHER; PTHR46009:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF04652; Vta1; 1.
DR Pfam; PF18097; Vta1_C; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 338..538
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 538 AA; 60146 MW; 37E8A6926D07BC2E CRC64;
MASVTQIPQS LRSIAHYVKI GAENADRDPI VHYWCLFYAV QTGMNIDKKS AEALQYLTSL
LSILEDMKKK LSGQEALTQD LVAQAHIENF AMKLFDYADK NDRQSNFTKG VVRAFYTAGH
LIDVLTLFGE LDENLIATRK YAKWKATYIH SCMKNGEIPK PGSGGNQDGN LKDFNMEIPQ
TEMRKEPQST TDGPIQPLPN SLGPSYIYSD SAPTVETCEL SHIPEAKRSS QEVSENSDSG
KLTLDDYMEA QKYAKYAVSA LSYEDSKTAI ESNEQTKKWM RKGLKLSVKI TVSWKRSKKV
IMFGRKSKSK NKNKKGQHAM EEVPIMPSFT GEHAIFAVPL SLAVLRMGSH DGIPLPVIVR
QCIDCINEKG LCVEGIHRIS APKANLDKLE KAVNSRYSIQ LEDIHDASGL LKRFLRQLPE
HILTNEKRPI FEKIAANCPC GTLSPCRCLV ADMLKAQLIL LPGENYMLLA YIFIHSQMIL
QNSDKNKMGM AALGLILQAT LNVSQSLVRI FLLNASDVIL MKYHSPSVSI SFGRNCIF
//
